Phenotypes associated with this allele

• Allele Symbol: Grin1^tm2Blt
• Allele Name: targeted mutation 2, Horst Bluethmann
• Allele ID: MGI:1928284
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin1^tm2Blt/Grin1^tm2Blt	involves: 129P2/OlaHsd * C57BL/6	MGI:2175050

Genotype
MGI:2175050

hm1

• Allelic Composition: Grin1^tm2Blt/Grin1^tm2Blt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:62289 )

• most die within 48 hours after birth, although occasionally survive to a maximum of 21 days

behavior/neurological

absent suckling reflex ( J:62289 )

• do not feed normally and milk is rarely visible in stomachs

growth/size/body

decreased body weight ( J:62289 )

• decrease in body weight at birth and those that survive past 48 hours fail to gain weight

postnatal growth retardation ( J:62289 )

• those that survive past 48 hours are retarded in physical development

nervous system

abnormal nervous system physiology ( J:62289 )

• exhibit reduced NMDA receptor glycine affinity, but not glutamate affinity, and do not have any gross CNS abnormalities