All Phenotypes Grin2a<tm1Mim> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grin2a^tm1Mim
targeted mutation 1, Masayoshi Mishina
MGI:1928285

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2a^tm1Mim/Grin2a^tm1Mim	B6.Cg-Grin2a^tm1Mim	MGI:4943913
hm2	Grin2a^tm1Mim/Grin2a^tm1Mim	involves: C57BL/6 * CBA	MGI:2175052
cx3	Grin2a^tm1Mim/Grin2a^tm1Mim Grin2c^tm1Mwa/Grin2c^tm1Mwa	involves: C57BL/6 * CBA	MGI:3055023

Allelic Composition	Grin2a^tm1Mim/Grin2a^tm1Mim
Genetic Background	B6.Cg-Grin2a^tm1Mim

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2a^tm1Mim mutation (1 available); any Grin2a mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased startle reflex ( J:89405 )

• enhanced startle response at sound levels of 100 - 110 dB

Allelic Composition	Grin2a^tm1Mim/Grin2a^tm1Mim
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2a^tm1Mim mutation (1 available); any Grin2a mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:22295 )

• take a longer time to reach the platform on the first block of trails on a visible-platform task; subsequently they perform similiarly to wild-type

• take significantly longer to locate the hidden platform in the hidden-platform task

• in the transfer test, homozygotes spend a significantly shorter time searching in the trained quadrant and cross the trained spot less often than wild-type

jumpy ( J:22295 )

• jumpy

nervous system

reduced NMDA-mediated synaptic currents ( J:22295 )

• significant reduction of the NMDA receptor channel current, however no differences in the current-voltage relationships of the NMDA receptor channel currents and the reversal potential

reduced long-term potentiation ( J:22295 )

• reduced LTP at the hippocampal CA1 synapses, however histological examination of various brain regions shows no abnormalities

Allelic Composition	Grin2a^tm1Mim/Grin2a^tm1Mim Grin2c^tm1Mwa/Grin2c^tm1Mwa
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2a^tm1Mim mutation (1 available); any Grin2a mutation (66 available)
Grin2c^tm1Mwa mutation (0 available); any Grin2c mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:92648 )

• a mild motor coordination impairment is seen in the rotating rod test at high speeds

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24