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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grin2btm1Rsp
targeted mutation 1, Rolf Sprengel
MGI:1928293
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grin2btm1Rsp/Grin2btm1Rsp involves: 129S1/Sv * 129X1/SvJ MGI:3847251
ht2
 		Grin2btm1Rsp/Grin2b+ involves: 129S1/Sv * 129X1/SvJ MGI:5505867


Genotype
MGI:3847251
hm1
Allelic
Composition		 Grin2btm1Rsp/Grin2btm1Rsp
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2btm1Rsp mutation (0 available); any Grin2b mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:45446 )
• homozygous mice dise shortly after birth

nervous system
abnormal NMDA-mediated synaptic currents ( J:45446 )
• in hippocampus slices from newborn homozygous mice, desensitization occurs in the presence of NMDA; however, the evoked current amplitudes are about half that of control mice




Genotype
MGI:5505867
ht2
Allelic
Composition		 Grin2btm1Rsp/Grin2b+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2btm1Rsp mutation (0 available); any Grin2b mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased anxiety-related response ( J:197485 )
• in an open field, mice travel more distance compared with wild-type mice

nervous system
reduced long-term potentiation ( J:197485 )
• following theta burst stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory