Phenotypes associated with this allele

• Allele Symbol: Grin2d^tm1Mim
• Allele Name: targeted mutation 1, Masayoshi Mishina
• Allele ID: MGI:1928298
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2d^tm1Mim/Grin2d^tm1Mim	B6.Cg-Grin2d^tm1Mim	MGI:4943924
hm2	Grin2d^tm1Mim/Grin2d^tm1Mim	involves: C57BL/6 * CBA	MGI:4360537

Genotype
MGI:4943924

hm1

• Allelic Composition: Grin2d^tm1Mim/Grin2d^tm1Mim
• Genetic Background: B6.Cg-Grin2d^tm1Mim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased startle reflex ( J:89405 )

• enhanced startle response at sound levels of 95 - 120 dB

Genotype
MGI:4360537

hm2

• Allelic Composition: Grin2d^tm1Mim/Grin2d^tm1Mim
• Genetic Background: involves: C57BL/6 * CBA

nervous system

nervous system phenotype ( J:28825 )

N • no gross histological abnormalities in the brain are seen

behavior/neurological

behavior/neurological phenotype ( J:28825 )

N • strength, endurance and balance appeared similar to controls in a rotating rod test

N • exploratory behavior, anxiety and novelty preference are not affected in mutant mice as assayed by a light-dark compartment test, an elevated plus maze test and an open-field test

decreased vertical activity ( J:28825 )

• reduced number of rearings compared to controls

decreased locomotor activity ( J:28825 )

• reduced total walking activity compared to controls