All Phenotypes Grin1<tm1Cur> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grin1^tm1Cur
targeted mutation 1, Tom Curran
MGI:1928327

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin1^tm1Cur/Grin1^tm1Cur	involves: 129S1/Sv * C57BL/6	MGI:2175047
ht2	Grin1^tm1Cur/Grin1^tm2.1Phs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3586703
ht3	Grin1^tm1Cur/Grin1^tm1.1Phs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3845918

Allelic Composition	Grin1^tm1Cur/Grin1^tm1Cur
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm1Cur mutation (0 available); any Grin1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:66345 )

• 8-15 hours after birth

respiratory system

lung hemorrhage ( J:66345 )

atelectasis ( J:66345 )

overexpanded pulmonary alveolus ( J:66345 )

homeostasis/metabolism

cyanosis ( J:66345 )

• at the time of death, mice have a gray-blue pallor suggestive of respiratory distress

cardiovascular system

cardiovascular system phenotype ( J:66345 )

N	• no overt signs of heart defects, cardiac infarction or ventricular enlargement, although signs of vascular congestion is noted

lung hemorrhage ( J:66345 )

behavior/neurological

absent gastric milk in neonates ( J:66345 )

nervous system

nervous system phenotype ( J:66345 )

N	• no obvious defects are present in the neuroarchitecture of the CNS, including brain stem regions that are implicated in regulating respiration, swallowing and in cardiac function

abnormal glutamate-mediated receptor currents ( J:66345 )

• cultured granule neuron cells from mutant mice show a depressed response to glutamate at low concentrations

absence of NMDA-mediated synaptic currents ( J:66345 )

• cultured granule neuron cells and hippocampal neurons from mutant mice do not respond to NMDA; intracellular calcium and membrane currents are abolished

Allelic Composition	Grin1^tm1Cur/Grin1^tm2.1Phs
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm1Cur mutation (0 available); any Grin1 mutation (66 available)
Grin1^tm2.1Phs mutation (0 available); any Grin1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:75497 )

• death within 1 hour of birth

behavior/neurological

aphagia ( J:75497 )

• no feeding

respiratory system

respiratory distress ( J:75497 )

Allelic Composition	Grin1^tm1Cur/Grin1^tm1.1Phs
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1^tm1.1Phs mutation (0 available); any Grin1 mutation (66 available)
Grin1^tm1Cur mutation (0 available); any Grin1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:75497 )

homeostasis/metabolism

cyanosis ( J:75497 )

behavior/neurological

aphagia ( J:75497 )

absent gastric milk in neonates ( J:75497 )

respiratory system

abnormal breathing pattern ( J:75497 )

abnormal pulmonary respiratory rate ( J:75497 )

respiratory distress ( J:75497 )

nervous system

absence of NMDA-mediated synaptic currents ( J:75497 )

• currents are not detectable in hippocampal CA1 pyramidal cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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