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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nrg1tm2Cbm
targeted mutation 2, Carmen Birchmeier
MGI:1928490
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nrg1tm2Cbm/Nrg1tm2Cbm involves: 129P2/OlaHsd MGI:2173313
hm2
Nrg1tm2Cbm/Nrg1tm2Cbm involves: 129P2/OlaHsd * C57BL/6 MGI:2175172
ht3
Nrg1tm2Cbm/Nrg1+ involves: 129P2/OlaHsd MGI:3835557


Genotype
MGI:2173313
hm1
Allelic
Composition
Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm2Cbm mutation (0 available); any Nrg1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• lack neural crest cell precursor cells in the anlage of the primary sympathetic ganglion chain
• reduced number of Schwann cell precursors that line the spinal nerves of the trunk, indicating that type III neuregulin is necessary and sufficient for Schwann cell precursor development

embryo
• severe reduction in the numbers of neural crest cells that migrate to the dorsal aorta

cellular
• severe reduction in the numbers of neural crest cells that migrate to the dorsal aorta




Genotype
MGI:2175172
hm2
Allelic
Composition
Nrg1tm2Cbm/Nrg1tm2Cbm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm2Cbm mutation (0 available); any Nrg1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• however, atria were morphologically normal
• at E10.5, the endocardial cusion was not closed, and the mesenchymal cells forming the cusion were reduced in number
• frequently observed
• frequently observed

muscle
• however, atria were morphologically normal

nervous system
• Schwann cell precursors in the trunk appear reduced in number
• cranial ganglia cells are reduced in number
• distinct ganglia are altered to different extents
• geniculate and vestibular-cochlea ganglia appear unaffected
• loss of neural-crest derived cells in the ganglia are thought to account for the morphological changes
• projections are disorganized; projections to CNS often absent
• projections are disorganized
• the jugular ganglion is described as abnormal
• cranial nerves are severely altered, whereas other peripheral projections appear normal
• mandibular projections and axonal connections between trigeminus and hindbrain are lost
• lost, particularly the dorsal part

growth/size/body
• frequently observed




Genotype
MGI:3835557
ht3
Allelic
Composition
Nrg1tm2Cbm/Nrg1+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm2Cbm mutation (0 available); any Nrg1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• thickness of the myelin sheath in the central nervous system is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory