nervous system
• lack neural crest cell precursor cells in the anlage of the primary sympathetic ganglion chain
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• reduced number of Schwann cell precursors that line the spinal nerves of the trunk, indicating that type III neuregulin is necessary and sufficient for Schwann cell precursor development
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embryo
• severe reduction in the numbers of neural crest cells that migrate to the dorsal aorta
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cellular
• severe reduction in the numbers of neural crest cells that migrate to the dorsal aorta
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