All Phenotypes Grin2a<tm1Nak> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2a^tm1Nak/Grin2a^tm1Nak	involves: 129S/SvEv	MGI:4360542
cx2	Grin2a^tm1Nak/Grin2a^tm1Nak Grin2c^tm1Nak/Grin2c^tm1Nak	involves: 129S/SvEv	MGI:4360543

Allelic Composition	Grin2a^tm1Nak/Grin2a^tm1Nak
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2a^tm1Nak mutation (7 available); any Grin2a mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:66455 )

N	• no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice

abnormal excitatory postsynaptic currents ( J:66455 )

• the rise time in evoked ESPCs is simutant mice do not exhibit impaired coordination in the fixed bar or rotarod test similar in mutant mice compared to controls, but the decay time is slower in mutant mice; the time constants of both fast and slow components of decay increased in mutant mice compared to controls

abnormal miniature excitatory postsynaptic currents ( J:66455 )

• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is reduced by approximately half in mutant mice compared to controls

behavior/neurological

behavior/neurological phenotype ( J:66455 )

N	• mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls • mutant mice do not exhibit impaired coordination in the fixed bar or rotarod tests

decreased vertical activity ( J:66455 )

• the amount of rearing activity is slightly reduced in mutant mice compared to controls

• there is no difference in horizontal locomotor activity compared to controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:66455 )

N	• no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice

abnormal excitatory postsynaptic currents ( J:66455 )

• evoked ESPCs are absent in cerebellar granule cells in double mutant mice

abnormal miniature excitatory postsynaptic currents ( J:66455 )

• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is nearly absent in mutant mice compared to controls

behavior/neurological

behavior/neurological phenotype ( J:66455 )

N	• mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls

impaired balance ( J:66455 )

• double mutant mice do not maintain balance and cannot stand or walk on a 6mm wide fixed bar while control mice can walk smoothly and stay on the bar

• on a 20mm fixed bar, mutant mice can can walk smoothly and stay on the bar, similar to controls

• on a rotating rod at 25 rpm, mutant mice fail to stay on the rod and do not improve performance with training

• at 10 and 20 rpm, mutant mice perform similar to controls

decreased vertical activity ( J:66455 )

• the amount of rearing activity is significantly reduced in mutant mice compared to controls

• there is no difference in horizontal locomotor activity compared to controls

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