About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Grin2atm1Nak
targeted mutation 1, Shigetada Nakanishi
MGI:1928506
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Grin2atm1Nak/Grin2atm1Nak involves: 129S/SvEv MGI:4360542
cx2
Grin2atm1Nak/Grin2atm1Nak
Grin2ctm1Nak/Grin2ctm1Nak
involves: 129S/SvEv MGI:4360543


Genotype
MGI:4360542
hm1
Allelic
Composition
Grin2atm1Nak/Grin2atm1Nak
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2atm1Nak mutation (7 available); any Grin2a mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice
• the rise time in evoked ESPCs is simutant mice do not exhibit impaired coordination in the fixed bar or rotarod test similar in mutant mice compared to controls, but the decay time is slower in mutant mice; the time constants of both fast and slow components of decay increased in mutant mice compared to controls
• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is reduced by approximately half in mutant mice compared to controls

behavior/neurological
N
• mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls
• mutant mice do not exhibit impaired coordination in the fixed bar or rotarod tests
• the amount of rearing activity is slightly reduced in mutant mice compared to controls
• there is no difference in horizontal locomotor activity compared to controls




Genotype
MGI:4360543
cx2
Allelic
Composition
Grin2atm1Nak/Grin2atm1Nak
Grin2ctm1Nak/Grin2ctm1Nak
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2atm1Nak mutation (7 available); any Grin2a mutation (66 available)
Grin2ctm1Nak mutation (1 available); any Grin2c mutation (56 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice
• evoked ESPCs are absent in cerebellar granule cells in double mutant mice
• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is nearly absent in mutant mice compared to controls

behavior/neurological
N
• mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls
• double mutant mice do not maintain balance and cannot stand or walk on a 6mm wide fixed bar while control mice can walk smoothly and stay on the bar
• on a 20mm fixed bar, mutant mice can can walk smoothly and stay on the bar, similar to controls
• on a rotating rod at 25 rpm, mutant mice fail to stay on the rod and do not improve performance with training
• at 10 and 20 rpm, mutant mice perform similar to controls
• the amount of rearing activity is significantly reduced in mutant mice compared to controls
• there is no difference in horizontal locomotor activity compared to controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory