All Phenotypes Grin2c<tm1Nak> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2c^tm1Nak/Grin2c^tm1Nak	involves: 129S/SvEv	MGI:4360541
cx2	Grin2a^tm1Nak/Grin2a^tm1Nak Grin2c^tm1Nak/Grin2c^tm1Nak	involves: 129S/SvEv	MGI:4360543

Allelic Composition	Grin2c^tm1Nak/Grin2c^tm1Nak
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2c^tm1Nak mutation (1 available); any Grin2c mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:66455 )

N	• no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice

abnormal excitatory postsynaptic currents ( J:66455 )

• the rise time in evoked ESPCs is similar in mutant mice compared to controls, but the decay time is faster in mutant mice; the time constants of both fast and slow components of decay decreased in mutant mice compared to controls

• there is no difference in horizontal locomotor activity compared to controls

abnormal miniature excitatory postsynaptic currents ( J:66455 )

• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is reduced by approximately half in mutant mice compared to controls

behavior/neurological

behavior/neurological phenotype ( J:66455 )

N	• mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls • mutant mice do not exhibit impaired coordination in the fixed bar or rotarod tests

decreased vertical activity ( J:66455 )

• the amount of rearing activity is slightly reduced in mutant mice compared to controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:66455 )

N	• no gross anatomical changes in the brain; the organization of the cerebellum is unaltered and the size and density of the granule cells is similar in mutant and control mice

abnormal excitatory postsynaptic currents ( J:66455 )

• evoked ESPCs are absent in cerebellar granule cells in double mutant mice

abnormal miniature excitatory postsynaptic currents ( J:66455 )

• the amplitude of the slow component (characteristic of NMDA receptor activity) of spontaneous ESPCs in cerebellar granule cells is nearly absent in mutant mice compared to controls

behavior/neurological

behavior/neurological phenotype ( J:66455 )

N	• mutant mice do not exhibit ataxia or tremors, and grip strength and righting reflex is similar to controls

impaired balance ( J:66455 )

• double mutant mice do not maintain balance and cannot stand or walk on a 6mm wide fixed bar while control mice can walk smoothly and stay on the bar

• on a 20mm fixed bar, mutant mice can can walk smoothly and stay on the bar, similar to controls

• on a rotating rod at 25 rpm, mutant mice fail to stay on the rod and do not improve performance with training

• at 10 and 20 rpm, mutant mice perform similar to controls

decreased vertical activity ( J:66455 )

• the amount of rearing activity is significantly reduced in mutant mice compared to controls

• there is no difference in horizontal locomotor activity compared to controls

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