Analysis Tools|
Allele Symbol Allele Name Allele ID |
Grin2ctm1Rsp targeted mutation 1, Rolf Sprengel MGI:1928514 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired balance is shown by a decreased retention time on a thin stationary plexiglass rod
• retention times on a rotarod is similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit reduced latency in the step-down avoidance task; these mice all exhibit jumping and vocalization upon shock, suggesting that this phenotype is not attributable to differences in pain perception
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• impaired motor coordination is shown by a decreased retention time on a rotarod and on a thin stationary plexiglass rod
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| N |
• mutant mice exhibit slightly reduced cerebellar NR1 levels, but comimmunoprecipitation experiments show that the NR1 and mutant subunits are associated with each other as well as with PSD-95
• synaptic activation of these mutant receptors evoked postsynaptic elevations of Ca2+ intracellular concentration, similar to the controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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