All Phenotypes Nkx3-1<tm1Siz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx3-1^tm1Siz
targeted mutation 1, Seigo Izumo
MGI:1928655

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx3-1^tm1Siz/Nkx3-1^tm1Siz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3027726

Allelic Composition	Nkx3-1^tm1Siz/Nkx3-1^tm1Siz
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1^tm1Siz mutation (0 available); any Nkx3-1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal salivary gland morphology ( J:64981 )

abnormal palatine gland morphology ( J:64981 )

decreased ductal branching in the palatine gland ( J:64981 )

increased salivary gland mucosal cell number ( J:64981 )

abnormal prostate gland morphology ( J:64981 )

abnormal prostate gland anterior lobe morphology ( J:64981 )

small prostate gland anterior lobe ( J:64981 )

decreased ductal branching in the coagulating gland ( J:64981 )

prostate gland lateral lobe hypoplasia ( J:64981 )

decreased prostate gland duct number ( J:64981 )

abnormal prostate gland epithelium morphology ( J:64981 )

• prostate epithelial dysplasia

prostate gland epithelial hyperplasia ( J:64981 )

small prostate gland ventral lobe ( J:64981 )

small seminal vesicle ( J:64981 )

reproductive system

abnormal prostate gland morphology ( J:64981 )

abnormal prostate gland anterior lobe morphology ( J:64981 )

small prostate gland anterior lobe ( J:64981 )

decreased ductal branching in the coagulating gland ( J:64981 )

prostate gland lateral lobe hypoplasia ( J:64981 )

decreased prostate gland duct number ( J:64981 )

abnormal prostate gland epithelium morphology ( J:64981 )

• prostate epithelial dysplasia

prostate gland epithelial hyperplasia ( J:64981 )

small prostate gland ventral lobe ( J:64981 )

small seminal vesicle ( J:64981 )

digestive/alimentary system

abnormal salivary gland morphology ( J:64981 )

abnormal palatine gland morphology ( J:64981 )

decreased ductal branching in the palatine gland ( J:64981 )

increased salivary gland mucosal cell number ( J:64981 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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