Phenotypes associated with this allele

• Allele Symbol: Uncx^tm1Pgr
• Allele Name: targeted mutation 1, Peter Gruss
• Allele ID: MGI:1928812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uncx^tm1Pgr/Uncx^tm1Pgr	involves: NMRI	MGI:2174797

Genotype
MGI:2174797

hm1

• Allelic Composition: Uncx^tm1Pgr/Uncx^tm1Pgr
• Genetic Background: involves: NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:62023 )

• die at birth, possibly due to respiratory failure

skeleton

abnormal axial skeleton morphology ( J:62023 )

abnormal thoracic cage morphology ( J:62023 )

• malformed rib cage, however the sternum and distal ribs appear normal

absent proximal rib ( J:62023 )

decreased rib number ( J:62023 )

• 13th rib is absent

rib fusion ( J:62023 )

• seen occasionally

kyphosis ( J:62023 )

absent vertebral pedicles ( J:62023 )

• pedicles of the neural arches are missing

fusion of vertebral bodies ( J:62023 )

• fusion of vertebral bodies is seen occasionally

abnormal sclerotome morphology ( J:62023 )

• condensation of the sclerotome is barely detectable at E11.5 and rostrocaudal polarity of the sclerotome is disrupted

nervous system

abnormal dorsal root ganglion morphology ( J:62023 )

disorganized dorsal root ganglion ( J:62023 )

• dorsal root ganglia are not regularly spaced, however the brain and spinal cord appear normal

fused dorsal root ganglion ( J:62023 )

abnormal spinal nerve morphology ( J:62023 )

• disorganized spinal nerves seen as continuous bundles without restrictions to the rostral half of the sclerotome

respiratory system

respiratory failure ( J:62023 )

• die at birth, possibly due to respiratory failure

renal/urinary system

renal/urinary system phenotype ( J:62023 )

N • no abnormal kidney phenotypes detected