Phenotypes associated with this allele

• Allele Symbol: Nrg1^tm1Gne
• Allele Name: targeted mutation 1, Genentech
• Allele ID: MGI:1928825
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrg1^tm1Gne/Nrg1^tm1Gne	either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6J)	MGI:2171462
hm2	Nrg1^tm1Gne/Nrg1^tm1Gne	involves: 129S2/SvPas * C57BL/6J	MGI:3530473
ht3	Nrg1^tm1Gne/Nrg1^+	B6.129S2-Nrg1^tm1Gne	MGI:5318195

Genotype
MGI:2171462

hm1

• Allelic Composition: Nrg1^tm1Gne/Nrg1^tm1Gne
• Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:45302 )

• embryos were present up to E10.5

cardiovascular system

absent trabeculae carneae ( J:45302 )

enlarged heart ( J:45302 )

thin ventricular wall ( J:45302 )

poor circulation ( J:45302 )

irregular heartbeat ( J:45302 )

muscle

absent trabeculae carneae ( J:45302 )

nervous system

abnormal cranial ganglia morphology ( J:45302 )

• abnormal postition of the vestibulocochlear and geniculate ganglia

abnormal petrosal ganglion morphology ( J:45302 )

• disorganized

small nodose ganglion ( J:45302 )

abnormal hypoglossal nerve morphology ( J:45302 )

• posterior branches were rudimentary and failed to coalesce with the C1 and vagus nerves

abnormal trigeminal nerve morphology ( J:45302 )

• the ophthalmic division was unfasciculated

absent mandibular nerve ( J:45302 )

abnormal dorsal root ganglion morphology ( J:45302 )

• moderate cell death apparent

abnormal ventral spinal root morphology ( J:45302 )

• the normal constriction of the ventral root was absent

• a delay in the development of projections from the posterior ganglia was observed

• ventral root projections are defasciculated

growth/size/body

enlarged heart ( J:45302 )

Genotype
MGI:3530473

hm2

• Allelic Composition: Nrg1^tm1Gne/Nrg1^tm1Gne
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

behavior/neurological

abnormal locomotor coordination ( J:62377 )

• improved motor coordination; mutant mice exhibit a faster improvement and could cope with the accelerating rod better by the end of the training than controls

hyperactivity ( J:62377 )

• observed at 6-7 months of age in an open-field test

• mice completed the T-maze test faster than controls, but showed no significant changes in alternation rate

Genotype
MGI:5318195

ht3

• Allelic Composition: Nrg1^tm1Gne/Nrg1⁺
• Genetic Background: B6.129S2-Nrg1^tm1Gne

nervous system

abnormal excitatory postsynaptic currents ( J:182690 )

• EPSCs remain elevated following theta-pulse stimulation (TPS) and slowly run down whereas in wild-type slices, LTP reversal is triggered by TPS

enhanced long-term potentiation ( J:182690 )

• significantly increased compared to controls (EPSC amplitude 322% vs 157%)

• after LTP induction, extended period of enhanced LTP is followed by a period of decreasing LTP