Phenotypes associated with this allele

• Allele Symbol: Erbb2^tm1Gne
• Allele Name: targeted mutation 1, Genentech
• Allele ID: MGI:1928827
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb2^tm1Gne/Erbb2^tm1Gne	either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6J)	MGI:2171457

Genotype
MGI:2171457

hm1

• Allelic Composition: Erbb2^tm1Gne/Erbb2^tm1Gne
• Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:45302 )

• homozygous embryos die around E10.5 probably from cardiovascular defects

cardiovascular system

absent myocardial trabeculae ( J:45302 )

enlarged heart ( J:45302 )

thin ventricular wall ( J:45302 )

poor circulation ( J:45302 )

irregular heartbeat ( J:45302 )

muscle

absent myocardial trabeculae ( J:45302 )

nervous system

abnormal cochlear ganglion morphology ( J:45302 )

• the geniculate ganglion appears fused to the vestibular ganglion

abnormal geniculate ganglion morphology ( J:45302 )

• the geniculate ganglion appears fused to the vestibular ganglion

• few axons project from the geniculate toward the second branchial arch

abnormal petrosal ganglion morphology ( J:45302 )

• the petrosal ganglion appears rounded and elongated and is positioned further from the nodose ganglion than normal

• both the glossopharyngeal and superior nerve fibers emerging from the petrosal ganglion are stunted

abnormal trigeminal ganglion morphology ( J:45302 )

• the posterior and mandibular portions of the trigeminal ganglion are absent and the maxillary portion is reduced in size

• scattered neurons occupy the space between the trigeminal ganglion and the geniculate ganglion

small superior vagus ganglion ( J:45302 )

abnormal glossopharyngeal nerve morphology ( J:45302 )

• stunted

abnormal hypoglossal nerve morphology ( J:45302 )

• the rootlets of the hypoglossal nerve are missing from the C1 plexus

abnormal vagus nerve morphology ( J:45302 )

• the vagal projections extend further ventrally than normal

abnormal dorsal root ganglion morphology ( J:45302 )

• the dorsal root ganglia are unfasciculated

abnormal ventral spinal root morphology ( J:45302 )

• ventral root projections are unfasciculated

growth/size/body

enlarged heart ( J:45302 )