All Phenotypes Erbb3<tm1Gne> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:45302 )

• die by E10.5

absent adrenergic chromaffin cells ( J:45302 )

• no chromaffin cells were detected

abnormal pancreas morphology ( J:45302 )

• at E13.5, the pancreas was not as developed as controls

• thinned mesenchyme at variable penetrance

abnormal cardiac epithelial to mesenchymal transition ( J:45302 )

• cushions lacked mesenchyme

abnormal heart morphology ( J:45302 )

abnormal myocardium layer morphology ( J:45302 )

• differentiation and thinckening of the myocardium at E13.5 was reduced compared to controls

abnormal myocardial trabeculae morphology ( J:45302 )

• trabeculation is mildly affected

abnormal heart development ( J:45302 )

thin atrioventricular cushion ( J:45302 )

abnormal atrioventricular valve development ( J:45302 )

• hypoplastic valves with little additional development after E13.5

• valves appear incapable of supporting cardiac function

poor circulation ( J:45302 )

atrioventricular valve regurgitation ( J:45302 )

• blood reflux through the valves is apparent at E13.5

impaired neuronal migration ( J:45302 )

• ectopic dopaminergic neurons are present in the mesencephalic tegmental neuroepithelium due to failure to migrate

absent adrenergic chromaffin cells ( J:45302 )

• no chromaffin cells were detected

abnormal enteric ganglia morphology ( J:45302 )

• enteric ganglia in the forming gut are greatly reduced

abnormal brain morphology ( J:45302 )

• absence of differentiated mesenchyme dorsal to the cerebellum

abnormal embryonic neuroepithelial layer differentiation ( J:45302 )

• the neuroepithelial layer surrounding the fourth ventricle remained rudimentary

• the tectal neuroepithelium failed to differentiate and stratify

• isthmus neuroepithelium was pyknotic

• sometimes, the tectal neuroepthelium was infolded near the cerebellum

• the tegmental neuroepithelium was developmentally delayed

abnormal cranial flexure morphology ( J:45302 )

• the midbrain flexure developed abnormally

abnormal brain ventricular system morphology ( J:45302 )

• the entire brain ventricular system failed to enlarge, probably due to reduced or absent cerebrospinal fluid production

abnormal choroid plexus morphology ( J:45302 )

• the lateral and the fourth ventricles exhibit an absence of fingerlike projections and a long base projection compared to controls

abnormal cerebral aqueduct morphology ( J:45302 )

abnormal midbrain morphology ( J:45302 )

• the mesenchyme separating the hypothalamus and ventral tegmentum and pons was thickened and abnormally oriented

abnormal forebrain morphology ( J:45302 )

abnormal neocortex morphology ( J:45302 )

• thinned neocortex

abnormal hindbrain morphology ( J:45302 )

abnormal cerebellar plate morphology ( J:45302 )

• very little differentiation and the entire plate was misshapen

abnormal pontine flexure morphology ( J:45302 )

decreased Purkinje cell number ( J:45302 )

absent cerebellum vermis ( J:45302 )

cerebellum hypoplasia ( J:45302 )

• observed at E13.5

abnormal glial cell morphology ( J:45302 )

decreased Schwann cell number ( J:45302 )

• Schwann cells are present in reduced numbers on the trigeminal ganglion and dorsal root ganglia

• few cells are present along the surface of axon projections from the dorsal root ganglia or cranial nerves

abnormal cranial ganglia morphology ( J:45302 )

small petrosal ganglion ( J:45302 )

• mispositioned ventrally and with abnormal nerve projections

abnormal trigeminal ganglion morphology ( J:45302 )

• absence of mandibular portion of the ganglion

• abnormal and disorganized nerve projections

• normal geniculate ganglion

• normal vestibulocochlear ganglion

small nodose ganglion ( J:45302 )

abnormal ventral spinal root morphology ( J:45302 )

• the ventral root constriction was absent

abnormal stomach epithelium morphology ( J:45302 )

• normal organization of stomach layers

• the mesenchyme and the epithelial lining appear thinned