All Phenotypes Trim28<tm1.1Ipc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trim28^tm1.1Ipc
targeted mutation 1.1, Pierre Chambon
MGI:1928907

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Nr5a1-cre)2Klp/0 Trim28^tm1.1Ipc/Trim28^tm1.1Ipc	involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J	MGI:7471250
cn2	Tg(Nr5a1-cre)2Klp/0 Trim28^tm1.1Ics/Trim28^tm1.1Ipc	involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J	MGI:7471248
cn3	Trim28^tm1.1Ipc/Trim28^tm1.2Ipc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5620619
cn4	Trim28^tm1.1Ipc/Trim28^tm1.1Ipc Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:4948089
cn5	Trim28^tm1Fca/Trim28^tm1.1Ipc Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:4948087

Allelic Composition	Tg(Nr5a1-cre)2Klp/0 Trim28^tm1.1Ipc/Trim28^tm1.1Ipc
Genetic Background	involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nr5a1-cre)2Klp mutation (1 available)
Trim28^tm1.1Ipc mutation (1 available); any Trim28 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovarian follicle morphology ( J:327192 )

• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized

• all follicles masculinized at age 4 months

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:327192 )

• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized

• all follicles masculinized at age 4 months

cellular

cellular phenotype ( J:327192 )

N	• normal apoptosis in ovaries at ages P20 and 8 weeks

Allelic Composition	Tg(Nr5a1-cre)2Klp/0 Trim28^tm1.1Ics/Trim28^tm1.1Ipc
Genetic Background	involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nr5a1-cre)2Klp mutation (1 available)
Trim28^tm1.1Ics mutation (0 available); any Trim28 mutation (36 available)
Trim28^tm1.1Ipc mutation (1 available); any Trim28 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:327192 )

• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

reproductive system

abnormal ovarian follicle morphology ( J:327192 )

• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

Allelic Composition	Trim28^tm1.1Ipc/Trim28^tm1.2Ipc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Trim28^tm1.1Ipc mutation (1 available); any Trim28 mutation (36 available)
Trim28^tm1.2Ipc mutation (0 available); any Trim28 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:178936 )

N	• embryos no normal yolk sac protrusions or trophoblast malformations

abnormal vitelline vasculature morphology ( J:178936 )

short rostral-caudal axis ( J:178936 )

embryonic growth arrest ( J:178936 )

• at E8.5

abnormal lateral plate mesoderm morphology ( J:178936 )

• shorter and wider than in control mice

wavy neural tube ( J:178936 )

nervous system

wavy neural tube ( J:178936 )

digestive/alimentary system

abnormal digestive system development ( J:178936 )

• failure of gut closure

cardiovascular system

abnormal vitelline vasculature morphology ( J:178936 )

Allelic Composition	Trim28^tm1.1Ipc/Trim28^tm1.1Ipc Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha5^{Tg(AMH-cre)1Flor} mutation (1 available); any Plekha5 mutation (109 available)
Trim28^tm1.1Ipc mutation (1 available); any Trim28 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:170392 )

N	• no defects are detected in Sertoli cell or spermatogonia proliferation at P5

abnormal spermatid morphology ( J:170392 )

• decrease in the number of mature spermatids

• spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle

decreased male germ cell number ( J:170392 )

• germ cell depletion

oligozoospermia ( J:170392 )

• the caudal epididymis contains few spermatozoa

decreased testis weight ( J:170392 )

• at 7 weeks and 12 months of age

testis degeneration ( J:170392 )

• testicular degeneration

abnormal spermiation ( J:170392 )

• mature spermatids are retained within the seminiferous epithelium

decreased litter size ( J:170392 )

• sire smaller litters when crossed to wild-type females

reduced male fertility ( J:170392 )

• sire fewer and smaller litters when crossed to wild-type females

endocrine/exocrine glands

decreased testis weight ( J:170392 )

• at 7 weeks and 12 months of age

testis degeneration ( J:170392 )

• testicular degeneration

cellular

abnormal spermatid morphology ( J:170392 )

• decrease in the number of mature spermatids

• spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle

decreased male germ cell number ( J:170392 )

• germ cell depletion

oligozoospermia ( J:170392 )

• the caudal epididymis contains few spermatozoa

Allelic Composition	Trim28^tm1Fca/Trim28^tm1.1Ipc Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:170392 )

N	• testes morphology is indistinguishable from controls at 7 weeks of age

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