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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scarb1tm1Dhu
targeted mutation 1, Dennis Huszar
MGI:1928989
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scarb1tm1Dhu/Scarb1tm1Dhu involves: 129S4/SvJae * BALB/cByJ MGI:2174743
cx2
 		Ldlrtm1Her/Ldlrtm1Her
Scarb1tm1Dhu/Scarb1tm1Dhu 		involves: 129S4/SvJae * BALB/c * C57BL/6J MGI:3623224


Genotype
MGI:2174743
hm1
Allelic
Composition		 Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic
Background		 involves: 129S4/SvJae * BALB/cByJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scarb1tm1Dhu mutation (0 available); any Scarb1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating cholesterol level ( J:47439 )
• serum cholesterol levels are 50-70% higher than control values
increased circulating HDL cholesterol level ( J:47439 )
• HDL levels are 51% greater than control values




Genotype
MGI:3623224
cx2
Allelic
Composition		 Ldlrtm1Her/Ldlrtm1Her
Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
Scarb1tm1Dhu mutation (0 available); any Scarb1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atherosclerotic lesions ( J:62371 )
• lesion size is significantly increased in males compared to LDL-receptor controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory