Phenotypes associated with this allele

• Allele Symbol: Erbb3^tm1Cbm
• Allele Name: targeted mutation 1, Carmen Birchmeier
• Allele ID: MGI:1929072
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb3^tm1Cbm/Erbb3^tm1Cbm	either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)	MGI:2175864

Genotype
MGI:2175864

hm1

• Allelic Composition: Erbb3^tm1Cbm/Erbb3^tm1Cbm
• Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:43515 )

• pups surviving to E18.5, die at birth

embryonic lethality during organogenesis, incomplete penetrance ( J:43515 )

• most die between E11.5 and E13.5, although some survive to term

behavior/neurological

unresponsive to tactile stimuli ( J:43515 )

• pups and E16.5 embryos do not respond to tactile stimulation

no spontaneous movement ( J:43515 )

• pups do not move and spontaneous movement is reduced in E16.5 embryos

growth/size/body

decreased body weight ( J:43515 )

• newborns show an average of 10% weight reduction

respiratory system

respiratory failure ( J:43515 )

• pups do not breathe and lung alveoli do not expand

nervous system

increased neuron apoptosis ( J:43515 )

• increase in apoptosis in the dorsal root ganglia at E13.5

abnormal PNS glial cell morphology ( J:43515 )

• absence of glial cells in the enteric nervous system

absent Schwann cell precursors ( J:43515 )

• absence of Schwann cell precursors accompanying peripheral nerves

neuron degeneration ( J:43515 )

• sensory neuron degeneration

motor neuron degeneration ( J:43515 )

• motor neurons start to form but subsequently degenerate

abnormal cranial ganglia morphology ( J:43515 )

• cranial ganglia are abnormal by E10 when they form

abnormal cranial nerve morphology ( J:43515 )

• cranial nerves are abnormal by E10 when they form

abnormal dorsal root ganglion morphology ( J:43515 )

• dorsal root ganglia form but subsequently degenerate

small dorsal root ganglion ( J:43515 )

• neuron numbers in the dorsal root ganglia are normal at E12.5, but are reduced by 70 and 82% at E14.5 and E18.5, respectively

homeostasis/metabolism

cyanosis ( J:43515 )

cellular

increased neuron apoptosis ( J:43515 )

• increase in apoptosis in the dorsal root ganglia at E13.5