Analysis Tools|
Allele Symbol Allele Name Allele ID |
Notch4tm1Grid targeted mutation 1, Tom Gridley MGI:1929139 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes display normal embryonic growth and adults are viable, fertile and indistinguishable from control littermates
• virgin, pregnant, and lactating females show no apparent defects in mammary gland development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• P5 retinas show a 17.4% reduction in the area covered by the vascular plexus relative to wild-type retinas, indicating a delay in retinal angiogenesis
• at P5, growth of the retinal vascular plexus is delayed to a greater extent than in mice homozygous for Notch4tm1(KOMP)Vlcg allele
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• P5 retinas show a 18.7% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal
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• P5 retinas show a 17.4% reduction in the area covered by the vascular plexus relative to wild-type retinas, indicating a delay in retinal angiogenesis
• at P5, growth of the retinal vascular plexus is delayed to a greater extent than in mice homozygous for Notch4tm1(KOMP)Vlcg allele
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• P5 retinas show a 18.7% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• P5 retinas show a 18.0% reduction in the area covered by the vascular plexus relative to wild-type retinas
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• P5 retinas show a 16.9% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal
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• P5 retinas show a 18.0% reduction in the area covered by the vascular plexus relative to wild-type retinas
|
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• P5 retinas show a 16.9% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• normal size at birth but weight was only about 80% that of controls at 3 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryonic blood vessels fail to invade trophoblast
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• pale yolk sacs lacking obvious blood vessels
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• did not complete embryonic turning
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• fewer somites formed
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• pale yolk sacs lacking obvious blood vessels
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• dorsal aortae lack lumens
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• severely disorganized intersomitic vessels
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• embryonic blood vessels fail to invade trophoblast
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• vasculogenesis was normal but subsequent remodeling failed
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• pale yolk sacs lacking obvious blood vessels
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• lacking lumens
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• anterior cardinal veins discontinuous or missing
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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