All Phenotypes Erbb3<tm2Cbm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb3^tm2Cbm/Erbb3^tm2Cbm	either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)	MGI:2175866
hm2	Erbb3^tm2Cbm/Erbb3^tm2Cbm	involves: 129P2/OlaHsd	MGI:3621546
cn3	Erbb3^tm2Cbm/Erbb3^tm3Cbm Erbb4^tm1Fej/Erbb4^tm1Fej Cnp^tm1(cre)Kan/?	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3835562
cx4	Erbb2^tm1Cbm/Erbb2⁺ Erbb3^tm2Cbm/Erbb3⁺ Nrg1^tm1Cbm/Nrg1⁺	involves: 129P2/OlaHsd	MGI:3530779

Allelic Composition	Erbb3^tm2Cbm/Erbb3^tm2Cbm
Genetic Background	either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^tm2Cbm mutation (0 available); any Erbb3 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:43515 )

• pups surviving to E18.5, die at birth

embryonic lethality during organogenesis, incomplete penetrance ( J:43515 )

• most die between E11.5 and E13.5, although some survive to term

behavior/neurological

unresponsive to tactile stimuli ( J:43515 )

• pups and E16.5 embryos do not respond to tactile stimulatio

no spontaneous movement ( J:43515 )

• pups do not move and spontaneous movement is reduced in E16.5 embryos

growth/size/body

decreased body weight ( J:43515 )

• newborns show an average of 10% weight reduction

respiratory system

respiratory failure ( J:43515 )

• pups do not breathe and lung alveoli do not expand

nervous system

increased neuron apoptosis ( J:43515 )

• increase in apoptosis in the dorsal root ganglia at E13.5

abnormal PNS glial cell morphology ( J:43515 )

• absence of glial cells in the enteric nervous system

absent Schwann cell precursors ( J:43515 )

• absence of Schwann cell precursors accompanying peripheral nerves

neuron degeneration ( J:43515 )

• sensory neuron degeneration

motor neuron degeneration ( J:43515 )

• motor neurons start to form but subsequently degenerate

abnormal cranial ganglia morphology ( J:43515 )

• cranial ganglia are abnormal by E10 when they form

abnormal cranial nerve morphology ( J:43515 )

• cranial nerves are abnormal by E10 when they form

abnormal dorsal root ganglion morphology ( J:43515 )

• dorsal root ganglia form but subsequently degenerate

small dorsal root ganglion ( J:43515 )

• neuron numbers in the dorsal root ganglia are normal at E12.5, but are reduced by 70 and 82% at E14.5 and E18.5, respectively

homeostasis/metabolism

cyanosis ( J:43515 )

cellular

increased neuron apoptosis ( J:43515 )

• increase in apoptosis in the dorsal root ganglia at E13.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent adrenergic chromaffin cells ( J:48515 )

• absent in the medulla at E13, E14, and E17.5

abnormal sympathetic system morphology ( J:48515 )

• neurofilament positive fibers throughout the residual sympathetic nervous system appear more coarse and have an increase in diameter

abnormal sympathetic ganglion morphology ( J:48515 )

abnormal paravertebral ganglion morphology ( J:48515 )

• severe defect in the more posterior portion of the sympathetic ganglion chain

abnormal superior cervical ganglion morphology ( J:48515 )

• presence of satellite cells in the superior cervical ganglion

small superior cervical ganglion ( J:48515 )

• hypoplasia of the superior cervical ganglion at E17.5

abnormal prevertebral ganglion morphology ( J:48515 )

• only remnants of the celiac and mesenteric ganglia are present

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:48515 )

• columnar organization of the adrenal gland epithelia appears disorganized at E17.5

absent adrenergic chromaffin cells ( J:48515 )

• absent in the medulla at E13, E14, and E17.5

homeostasis/metabolism

decreased noradrenaline level ( J:48515 )

• 15-fold reduction in noradrenaline levels at E12.5

embryo

abnormal neural crest cell migration ( J:48515 )

• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions

• drastic reduction in the numbers of neural crest cells that migrate from the posterior portion of the primary ganglion chain to the mesentery or the anlage of the adrenal gland

cellular

abnormal neural crest cell migration ( J:48515 )

• neural crest cells are scarce at positions ventral of the neural tube and lateral of the dorsal aorta and accumulate at dorsal positions

• drastic reduction in the numbers of neural crest cells that migrate from the posterior portion of the primary ganglion chain to the mesentery or the anlage of the adrenal gland

Allelic Composition	Erbb3^tm2Cbm/Erbb3^tm3Cbm Erbb4^tm1Fej/Erbb4^tm1Fej Cnp^tm1(cre)Kan/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnp^tm1(cre)Kan mutation (0 available); any Cnp mutation (27 available)
Erbb3^tm2Cbm mutation (0 available); any Erbb3 mutation (48 available)
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (48 available)
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:145464 )

• develop to term but die in the second post natal week

nervous system

nervous system phenotype ( J:145464 )

N	• central nervous system myelination is normal up to 11 days of age (optic nerve and corpus callosum)

abnormal myelination ( J:145464 )

• severely defective myelination in the peripheral nervous system

Allelic Composition	Erbb2^tm1Cbm/Erbb2⁺ Erbb3^tm2Cbm/Erbb3⁺ Nrg1^tm1Cbm/Nrg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Cbm mutation (0 available); any Erbb2 mutation (61 available)
Erbb3^tm2Cbm mutation (0 available); any Erbb3 mutation (48 available)
Nrg1^tm1Cbm mutation (0 available); any Nrg1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelination ( J:90038 )

• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age

abnormal nerve conduction ( J:90038 )

• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials

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