mortality/aging
• homozygous embryos die between E10 and E11
|
cardiovascular system
• the remainder of the endocardium appears normal
|
• severely reduced embryonic blood flow as evidenced by an increased number of red blood cells in the heart
|
nervous system
• the geniculate (facial) ganglion exhibits motor axon projections to rhombomeres 1, 2, 3, 4 and 5 instead of just 4 and 5 as seen in controls
|
• abnormal innervation to and from the hindbrain to the crainial ganglia observed at E10.5
• the geniculate (facial) ganglion exhibits sensory neuron projections to rhombomeres 2 and 4 compared to only rhombomere 2 in controls
• the trigeminal ganglion exhibits sensory neuron projections to rhombomere 2 and 4 compared to only rhombomere 2 in controls
|
• nearly fused to ganglion V (trigeminal)
|
• nearly fused to ganglion V (trigeminal)
|
• nearly fused to ganglion VII/VIII (geniculate/vestibulocohlear)
|
• abnormal neuronal projections to the hindbrain
|
• mispositioned caudally
|
• abnormal neuronal projections to the hindbrain
|
muscle