All Phenotypes Tg(Trp53R172H)8512Jmr MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Trp53R172H)8512Jmr
transgene insertion 8512, Jeffrey Rosen
MGI:1929642

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(MMTVneu)202Mul/0 Tg(Trp53R172H)8512Jmr/0	C.FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr	MGI:3799373
cx2	Tg(MMTV-neu/OT-I/OT-II)CBnel/? Tg(Trp53R172H)8512Jmr/?	involves: C57BL/6 * FVB	MGI:3761175
cx3	Tg(MMTVneu)202Mul/0 Tg(Trp53R172H)8512Jmr/0	involves: FVB	MGI:3799447
tg4	Tg(Trp53R172H)8512Jmr/0	involves: FVB	MGI:3799369

Allelic Composition	Tg(MMTVneu)202Mul/0 Tg(Trp53R172H)8512Jmr/0
Genetic Background	C.FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:115041 )

• most mice die by 11 to 12 weeks of age due to overgrowth of the poorly differentiated and invasive carcinoma and lung metastases

• all mice die prior to 18 weeks of age

neoplasm

increased parotid gland tumor incidence ( J:115041 )

• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice

increased mammary adenocarcinoma incidence ( J:115041 )

• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age

increased lung tumor incidence ( J:115041 )

• mice exhibit lung metastases

endocrine/exocrine glands

increased parotid gland tumor incidence ( J:115041 )

• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice

increased mammary adenocarcinoma incidence ( J:115041 )

• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age

digestive/alimentary system

increased parotid gland tumor incidence ( J:115041 )

• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice

integument

increased mammary adenocarcinoma incidence ( J:115041 )

• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age

respiratory system

increased lung tumor incidence ( J:115041 )

• mice exhibit lung metastases

craniofacial

increased parotid gland tumor incidence ( J:115041 )

• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice

growth/size/body

increased parotid gland tumor incidence ( J:115041 )

• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice

Allelic Composition	Tg(MMTV-neu/OT-I/OT-II)CBnel/? Tg(Trp53R172H)8512Jmr/?
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-neu/OT-I/OT-II)CBnel mutation (1 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

integument

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:122846

Allelic Composition	Tg(MMTVneu)202Mul/0 Tg(Trp53R172H)8512Jmr/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:40336 )

• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days

• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone

• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone

• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

cellular

aneuploidy ( J:40336 )

• tumors exhibit aneuploidy and tetraploidy unlike in tumors from mice expressing Tg(MMTVneu)202Mul alone that are euploidy

polyploidy ( J:40336 )

• tumors exhibit aneuploidy and tetraploidy unlike in tumors from mice expressing Tg(MMTVneu)202Mul alone that are euploidy

integument

increased mammary gland tumor incidence ( J:40336 )

• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone

• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone

• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:40336 )

• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone

• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone

• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

Allelic Composition	Tg(Trp53R172H)8512Jmr/0
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53R172H)8512Jmr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

increased incidence of tumors by chemical induction ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

cellular

chromosomal instability ( J:46426 )

• tumor cells exhibit an increase in genomic instability (tetraploid and aneuploid) compared to tumor cells in wild-type mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:46426 )

N	• mammary gland development is normal

increased mammary adenocarcinoma incidence ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

integument

increased mammary adenocarcinoma incidence ( J:46426 )

• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice

• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:46426

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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