neoplasm
N |
• despite expression of the transgene, mice do not exhibit an increase in spontaneous tumor rates
|
endocrine/exocrine glands
• during lactation, mammary glands exhibit incomplete development with few normal lobuloalveolar structures compared to in wild-type mice
|
• mice exhibit increased mammary gland cell sensitivity to radiation induced apoptosis compared to in similarly treated wild-type mice
|
• females fail to lactate resulting in reduced pup weight and increased pup mortality
|
integument
• during lactation, mammary glands exhibit incomplete development with few normal lobuloalveolar structures compared to in wild-type mice
|
• mice exhibit increased mammary gland cell sensitivity to radiation induced apoptosis compared to in similarly treated wild-type mice
|
• females fail to lactate resulting in reduced pup weight and increased pup mortality
|
• mice exhibit follicular dilatation and comedo formation
|
skin lesions
(
J:56433
)
• lesions in the hind quarter represent follicular dilatation and comedo formation
|