All Phenotypes Bdnf<tm1Par> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bdnf^tm1Par
targeted mutation 1, Luis Parada
MGI:1929986

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bdnf^tm1Par/Bdnf^tm1Par	involves: 129S1/Sv	MGI:2175722
ht2	Bdnf^tm1Par/Bdnf⁺	B6.129S1-Bdnf^tm1Par	MGI:3664866
ht3	Bdnf^tm1Par/Bdnf⁺	involves: 129S1/Sv	MGI:3664865
cx4	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes	MGI:3833380
cx5	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2⁺	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes	MGI:3833382
cx6	Bdnf^tm1Par/Bdnf^tm1Par Ntf3^tm1Par/Ntf3^tm1Par	involves: 129S1/Sv	MGI:3612887
cx7	Bdnf^tm1Par/Bdnf^tm1Par Ntf5^tm1Par/Ntf5^tm1Par	involves: 129S1/Sv * C57BL/6	MGI:3613013

Allelic Composition	Bdnf^tm1Par/Bdnf^tm1Par
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:44286 )

• die within 2 weeks of birth

nervous system

increased neuron apoptosis ( J:60927 )

• increase in dorsal root ganglion neuron apoptosis

abnormal barrel cortex morphology ( J:103935 )

• delay in barrel formation through P6, but the deficiency disappears by P8

abnormal somatic nervous system morphology ( J:44286 )

abnormal sensory neuron innervation pattern ( J:103935 )

• innervation into layer IV of the cortex by thalamic axons is uniform (rather than segregated into individual barrels) at P6, but becomes less apparent by P8

decreased sensory neuron number ( J:44286 , J:60927 )

• reduction of neurons in sensory ganglia, however motor neuron numbers are normal (J:44286)

• majority of sensory neuron loss occurs before E13.5 (J:44286)

small geniculate ganglion ( J:44286 )

• 50% reduction of neurons in the geniculate ganglion

small petrosal ganglion ( J:44286 )

• 39% reduction of neurons in the nodose/petrosal ganglion

small trigeminal ganglion ( J:44286 , J:60927 )

• 21% reduction of neurons in the trigeminal ganglion (J:44286)

small nodose ganglion ( J:44286 )

• 39% reduction of neurons in the nodose/petrosal ganglion

abnormal dorsal root ganglion morphology ( J:60927 )

• dorsal root ganglion neuronal cultures exhibit about 50% reduction in numbers of Bdnf and Ntf5-responsive neurons, but not of Ntf3-responsive neruons

small L4 dorsal root ganglion ( J:44286 )

• 36% reduction of neurons in the L4 dorsal root ganglion

small dorsal root ganglion ( J:60927 )

• 31% reduction of dorsal root ganglion neurons by E13

cellular

increased neuron apoptosis ( J:60927 )

• increase in dorsal root ganglion neuron apoptosis

Allelic Composition	Bdnf^tm1Par/Bdnf⁺
Genetic Background	B6.129S1-Bdnf^tm1Par

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

polyphagia ( J:59077 )

• age-related increase in food intake beggining around 6 weeks of age

• by 4-7 months of age mice consume about 25% more food than wild-type littermates

• chronic fluoxetine treatment partially suppresses hyperphagia

increased aggression towards male mice ( J:59077 , J:144845 )

• decrease in latency to attack an intruder and increase in number of biting attacks (J:59077)

• latency to attack progressively decreases over repeated trials (J:59077)

• treatment with fluoxetine reduced aggression to a level similar to that in wild-type mice (J:59077)

• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls (J:144845)

• male mice also have a significantly increased number of biting attacks over a 5 minute period (J:144845)

abnormal locomotor activation ( J:59077 )

• increased time spent in the center area during a 10 minute period in and open field; however, overall locomotor activity in an open field is not different from wild-type

decreased vertical activity ( J:59077 )

• during a 10 minute trial in an open field

growth/size/body

increased body weight ( J:144845 )

• mice gain weight with age with a mean 10 gram difference occurring by 6 months of age

increased susceptibility to age related obesity ( J:59077 )

• first detected at 2-4 months of age and by 12-18 months of age body weight is 34% higher than wild-type littermates

nervous system

abnormal serotonergic neuron morphology ( J:59077 )

• progressive loss of serotonin axons is seen in 12 to 18 month old mice

abnormal CNS synaptic transmission ( J:59077 )

• abnormal induction of Fos by dexfenfluramine (reduced in the bed nucleus of the stria terminalis, the central nucleus of the amygdala, parts of the caudate-putamen, the shell region of the nucleus accumbens, and the thalamic nuclei; increased in the pyramidal neurons of the hippocampus) indicates abnormal neuronal activation induced by 5-HT release

homeostasis/metabolism

increased circulating insulin level ( J:59077 )

• about 2-fold higher at 12 months of age

abnormal serotonin level ( J:59077 )

• forebrain levels of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) are significantly lower in old but not in young mice

• at 18 months of age the ratio of 5-HIAA to 5-HT is lower in the hypothalamus

Allelic Composition	Bdnf^tm1Par/Bdnf⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:113019 )

• decreased exploratory behavior as measured by percentage of time spent in the center and number of entries into the center of and open field over a 2 hour period; however no significant change in total locomotor activity is detected

increased aggression towards male mice ( J:113019 )

• increase in intermale aggression

increased anxiety-related response ( J:113019 )

• decrease in time spent in the open arms and numbers of entries into the open arms in an elevated plus maze

nervous system

decreased hippocampus volume ( J:113019 )

• 13.8 +/- 0.6% reduction in hippocampal volume

growth/size/body

increased body weight ( J:113019 )

• first detected at 2 months of age

Allelic Composition	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2^tm1.1Tes
Genetic Background	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)
Ntrk2^tm1.1Tes mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased aggression towards male mice ( J:144845 )

• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls

• male mice also have a significantly increased number of biting attacks over a 5 minute period

• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnf^tm1Par mutant allele

growth/size/body

increased body weight ( J:144845 )

• mice gain weight with age though not to the degree as mice that only carry the Bdnf^tm1Par mutant allele

Allelic Composition	Bdnf^tm1Par/Bdnf⁺ Ntrk2^tm1.1Tes/Ntrk2⁺
Genetic Background	B6.129S1-Bdnf^tm1Par Ntrk2^tm1.1Tes

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased aggression towards male mice ( J:144845 )

• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls

• male mice also have a significantly increased number of biting attacks over a 5 minute period

• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnf^tm1Par mutant allele

Allelic Composition	Bdnf^tm1Par/Bdnf^tm1Par Ntf3^tm1Par/Ntf3^tm1Par
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)
Ntf3^tm1Par mutation (0 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:44286 )

• die within the first day of birth

nervous system

abnormal somatic nervous system morphology ( J:44286 )

abnormal vestibulocochlear ganglion morphology ( J:44286 )

• 100% reduction of neurons in the spiral ganglia

decreased sensory neuron number ( J:44286 )

• reduction of neurons in sensory ganglia, however motor neuron numbers are normal

• sensory neuron loss occurs from E12.5 to P0.5

small geniculate ganglion ( J:44286 )

• 65% reduction of neurons in the geniculate ganglion

small petrosal ganglion ( J:44286 )

• 62% reduction of neurons in the nodose/petrosal ganglion

small trigeminal ganglion ( J:44286 )

• 74% reduction of neurons in the trigeminal ganglion

small nodose ganglion ( J:44286 )

• 62% reduction of neurons in the nodose/petrosal ganglion

abnormal vestibular ganglion morphology ( J:44286 )

• 100% reduction of neurons in the vestibular ganglia

small L4 dorsal root ganglion ( J:44286 )

• 83% reduction of neurons in the L4 dorsal root ganglion

Allelic Composition	Bdnf^tm1Par/Bdnf^tm1Par Ntf5^tm1Par/Ntf5^tm1Par
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Par mutation (0 available); any Bdnf mutation (42 available)
Ntf5^tm1Par mutation (0 available); any Ntf5 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:60927 )

• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation, however numbers of sensory neurons are normal

abnormal dorsal root ganglion morphology ( J:60927 )

• dorsal root ganglion neuronal cultures exhibit reduced numbers of Bdnf and Ntf5-responsive neurons and increased numbers of Ntf3-dependent neurons

cellular

abnormal neuron differentiation ( J:60927 )

• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation, however numbers of sensory neurons are normal

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