All Phenotypes Gdf9<tm1Zuk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gdf9^tm1Zuk
targeted mutation 1, Martin M Matzuk
MGI:1930111

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf9^tm1Zuk/Gdf9^tm1Zuk	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2175038
cx2	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9^tm1Zuk	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)	MGI:2652044
cx3	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9⁺	involves: 129S7/SvEvBrd	MGI:2652043
cx4	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2652042

Allelic Composition	Gdf9^tm1Zuk/Gdf9^tm1Zuk
Genetic Background	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf9^tm1Zuk mutation (0 available); any Gdf9 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:35782 )

• absent thecal layer

• asymmetrical granulosa cell layer

absent corpus luteum ( J:35782 )

abnormal ovarian folliculogenesis ( J:35782 )

• abnormal ovarian folliculogenesis seen beyond the one layer follicle stage

absent mature ovarian follicles ( J:35782 )

small ovary ( J:35782 )

• decreased ovary size visible as early as one week of age

ovary cyst ( J:35782 )

• observed in ages 25-31 weeks

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:35782 )

• increased 3-fold

increased circulating luteinizing hormone level ( J:35782 )

• increased 2-fold

reproductive system

abnormal oogenesis ( J:35782 )

abnormal ovary morphology ( J:35782 )

• asymmetrical granulosa cell layer

• absent thecal layer

absent corpus luteum ( J:35782 )

abnormal ovarian folliculogenesis ( J:35782 )

• abnormal ovarian folliculogenesis seen beyond the one layer follicle stage

absent mature ovarian follicles ( J:35782 )

small ovary ( J:35782 )

• decreased ovary size visible as early as one week of age

ovary cyst ( J:35782 )

• observed in ages 25-31 weeks

female infertility ( J:35782 )

• females, but not males, are infertile

growth/size/body

ovary cyst ( J:35782 )

• observed in ages 25-31 weeks

cellular

abnormal oogenesis ( J:35782 )

Allelic Composition	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9^tm1Zuk
Genetic Background	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp15^tm1Zuk mutation (0 available); any Bmp15 mutation (3 available)
Gdf9^tm1Zuk mutation (0 available); any Gdf9 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent oocytes ( J:69611 )

• loss of oocytes

abnormal zona pellucida morphology ( J:69611 )

• ovaries show increased zona pellucida remnants

abnormal ovary morphology ( J:69611 )

• proliferation of cells in the interstitium

impaired ovarian folliculogenesis ( J:69611 )

• block at the one layer follicle stage

ovary cyst ( J:69611 )

• uni- and bilateral ovarian cysts; only one cyst per ovary is present

female infertility ( J:69611 )

endocrine/exocrine glands

abnormal ovary morphology ( J:69611 )

• proliferation of cells in the interstitium

impaired ovarian folliculogenesis ( J:69611 )

• block at the one layer follicle stage

ovary cyst ( J:69611 )

• uni- and bilateral ovarian cysts; only one cyst per ovary is present

cellular

absent oocytes ( J:69611 )

• loss of oocytes

abnormal zona pellucida morphology ( J:69611 )

• ovaries show increased zona pellucida remnants

growth/size/body

ovary cyst ( J:69611 )

• uni- and bilateral ovarian cysts; only one cyst per ovary is present

Allelic Composition	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal oocyte morphology ( J:69611 )

• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

• superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

• increase in oocyte loss

abnormal zona pellucida morphology ( J:69611 )

• ovaries show an increase in zona pellucida remnants

absent corpus luteum ( J:69611 )

decreased mature ovarian follicle number ( J:69611 )

absent cumulus expansion ( J:69611 )

• failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

• observe follicles with multiple oocytes

female infertility ( J:69611 )

• Background Sensitivity: unlike on a mixed background where females are subfertile, females on the 129S7/SvEvBrd background completely fail to produce any offspring over a 6 month breeding period

endocrine/exocrine glands

absent corpus luteum ( J:69611 )

decreased mature ovarian follicle number ( J:69611 )

absent cumulus expansion ( J:69611 )

• failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

• observe follicles with multiple oocytes

cellular

abnormal oocyte morphology ( J:69611 )

• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

• superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

• increase in oocyte loss

abnormal zona pellucida morphology ( J:69611 )

• ovaries show an increase in zona pellucida remnants

Allelic Composition	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal oocyte morphology ( J:69611 )

• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

• superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

• increase in oocyte loss such that by 1 year of age, very few oocytes are present

abnormal zona pellucida morphology ( J:69611 )

• ovaries show an increase in zona pellucida remnants

absent corpus luteum ( J:69611 )

decreased mature ovarian follicle number ( J:69611 )

absent cumulus expansion ( J:69611 )

• failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

• observe follicles with multiple oocytes

reduced female fertility ( J:69611 )

• Background Sensitivity: females on a mixed 129S7/SvEvBrd and C57BL/6J background give birth to litters of reduced size, less frequently and are not completely infertile as on a 129S7/SvEvBrd background

decreased litter size ( J:69611 )

• average litter size is 3.67 (+/- 0.22) on mixed background

endocrine/exocrine glands

absent corpus luteum ( J:69611 )

decreased mature ovarian follicle number ( J:69611 )

absent cumulus expansion ( J:69611 )

• failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

• observe follicles with multiple oocytes

cellular

abnormal oocyte morphology ( J:69611 )

• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

• superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

• increase in oocyte loss such that by 1 year of age, very few oocytes are present

abnormal zona pellucida morphology ( J:69611 )

• ovaries show an increase in zona pellucida remnants

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