All Phenotypes Gdf9<tm1Zuk> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gdf9^tm1Zuk
targeted mutation 1, Martin M Matzuk
MGI:1930111

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gdf9^tm1Zuk/Gdf9^tm1Zuk	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)	MGI:2175038
cx2	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9^tm1Zuk	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)	MGI:2652044
cx3	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9⁺	involves: 129S7/SvEvBrd	MGI:2652043
cx4	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2652042

Allelic Composition	Gdf9^tm1Zuk/Gdf9^tm1Zuk
Genetic Background	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf9^tm1Zuk mutation (0 available); any Gdf9 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:35782 )

• asymmetrical granulosa cell layer

• absent thecal layer

absent corpus luteum ( J:35782 )

abnormal ovarian folliculogenesis ( J:35782 )

• abnormal ovarian folliculogenesis seen beyond the one layer follicle stage

absent mature ovarian follicles ( J:35782 )

small ovary ( J:35782 )

• decreased ovary size visible as early as one week of age

ovary cyst ( J:35782 )

• observed in ages 25-31 weeks

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:35782 )

• increased 3-fold

increased circulating luteinizing hormone level ( J:35782 )

• increased 2-fold

reproductive system

abnormal oogenesis ( J:35782 )

abnormal ovary morphology ( J:35782 )

• asymmetrical granulosa cell layer

• absent thecal layer

absent corpus luteum ( J:35782 )

abnormal ovarian folliculogenesis ( J:35782 )

• abnormal ovarian folliculogenesis seen beyond the one layer follicle stage

absent mature ovarian follicles ( J:35782 )

small ovary ( J:35782 )

• decreased ovary size visible as early as one week of age

ovary cyst ( J:35782 )

• observed in ages 25-31 weeks

female infertility ( J:35782 )

• females, but not males, are infertile

growth/size/body

ovary cyst ( J:35782 )

• observed in ages 25-31 weeks

cellular

abnormal oogenesis ( J:35782 )

Allelic Composition	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9^tm1Zuk
Genetic Background	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp15^tm1Zuk mutation (0 available); any Bmp15 mutation (3 available)
Gdf9^tm1Zuk mutation (0 available); any Gdf9 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent oocytes ( J:69611 )

• loss of oocytes

abnormal zona pellucida morphology ( J:69611 )

• ovaries show increased zona pellucida remnants

abnormal ovary morphology ( J:69611 )

• proliferation of cells in the interstitium

impaired ovarian folliculogenesis ( J:69611 )

• block at the one layer follicle stage

ovary cyst ( J:69611 )

• uni- and bilateral ovarian cysts; only one cyst per ovary is present

female infertility ( J:69611 )

endocrine/exocrine glands

abnormal ovary morphology ( J:69611 )

• proliferation of cells in the interstitium

impaired ovarian folliculogenesis ( J:69611 )

• block at the one layer follicle stage

ovary cyst ( J:69611 )

• uni- and bilateral ovarian cysts; only one cyst per ovary is present

cellular

absent oocytes ( J:69611 )

• loss of oocytes

abnormal zona pellucida morphology ( J:69611 )

• ovaries show increased zona pellucida remnants

growth/size/body

ovary cyst ( J:69611 )

• uni- and bilateral ovarian cysts; only one cyst per ovary is present

Allelic Composition	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal oocyte morphology ( J:69611 )

• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

• superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

• increase in oocyte loss

abnormal zona pellucida morphology ( J:69611 )

• ovaries show an increase in zona pellucida remnants

absent corpus luteum ( J:69611 )

decreased mature ovarian follicle number ( J:69611 )

absent cumulus expansion ( J:69611 )

• failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

• observe follicles with multiple oocytes

female infertility ( J:69611 )

• Background Sensitivity: unlike on a mixed background where females are subfertile, females on the 129S7/SvEvBrd background completely fail to produce any offspring over a 6 month breeding period

endocrine/exocrine glands

absent corpus luteum ( J:69611 )

decreased mature ovarian follicle number ( J:69611 )

absent cumulus expansion ( J:69611 )

• failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

• observe follicles with multiple oocytes

cellular

abnormal oocyte morphology ( J:69611 )

• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

• superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

• increase in oocyte loss

abnormal zona pellucida morphology ( J:69611 )

• ovaries show an increase in zona pellucida remnants

Allelic Composition	Bmp15^tm1Zuk/Bmp15^tm1Zuk Gdf9^tm1Zuk/Gdf9⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal oocyte morphology ( J:69611 )

• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

• superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

• increase in oocyte loss such that by 1 year of age, very few oocytes are present

abnormal zona pellucida morphology ( J:69611 )

• ovaries show an increase in zona pellucida remnants

absent corpus luteum ( J:69611 )

decreased mature ovarian follicle number ( J:69611 )

absent cumulus expansion ( J:69611 )

• failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

• observe follicles with multiple oocytes

reduced female fertility ( J:69611 )

• Background Sensitivity: females on a mixed 129S7/SvEvBrd and C57BL/6J background give birth to litters of reduced size, less frequently and are not completely infertile as on a 129S7/SvEvBrd background

decreased litter size ( J:69611 )

• average litter size is 3.67 (+/- 0.22) on mixed background

endocrine/exocrine glands

absent corpus luteum ( J:69611 )

decreased mature ovarian follicle number ( J:69611 )

absent cumulus expansion ( J:69611 )

• failure of cumulus expansion

polyovular ovarian follicle ( J:69611 )

• observe follicles with multiple oocytes

cellular

abnormal oocyte morphology ( J:69611 )

• cumulus cells fail to adhere to oocytes removed from the oviducts of superovulated mice

• superovulated females sometimes contain large denuded oocytes

decreased oocyte number ( J:69611 )

• increase in oocyte loss such that by 1 year of age, very few oocytes are present

abnormal zona pellucida morphology ( J:69611 )

• ovaries show an increase in zona pellucida remnants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24