All Phenotypes Ntrk2<tm1Kln> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk2^tm1Kln/Ntrk2^tm1Kln	involves: 129S1/Sv * 129X1/SvJ	MGI:2175188
ht2	Ntrk2^tm1Kln/Ntrk2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5575867
ht3	Ntrk2^tm1Bbd/Ntrk2^tm1Kln	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3708465
cx4	Ntrk2^tm1Kln/Ntrk2^tm1Kln Ntrk3^tm1Kln/Ntrk3^tm1Kln	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2656338
cx5	Bdnf^tm1Jae/Bdnf^tm2(Ntf5)Jae Ntrk2^tm1Kln/Ntrk2^tm1Kln	involves: 129S4/SvJae	MGI:3583673
cx6	Bdnf^tm2(Ntf5)Jae/Bdnf^tm2(Ntf5)Jae Ntrk2^tm1Kln/Ntrk2^tm1Kln	involves: 129S4/SvJae	MGI:3583672

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal synapse morphology ( J:75365 )

• failure of synapse formation in vestibular sensory epithelia ; no fibers or synapses are seen in the canal epithelia and only small synaptic contacts or partial calyces are seen in the utricle or saccular epithelia, respectively

small vestibular ganglion ( J:49472 )

• vestibular ganglia are reduced in volume and cell number by about 25% at P7 and in adulthood, but not at birth

abnormal vestibulocochlear nerve morphology ( J:75365 )

• reduction in the diameter and area of the posterior vertical crista nerve

• posterior vertical crista nerve shows a reduction in size of individual fibers at P26 and P70

abnormal vestibular nerve morphology ( J:75365 )

• cell body sizes of vestibular neurons are modestly reduced; soma sizes at P7 and P70 are 21% and 27% smaller, respectively

• 25% reduction of NTRK2-dependent vestibular neurons at P7, the remaining 75% of vestibular neurons survive to adulthood

abnormal somatic sensory system morphology ( J:49472 , J:75365 )

• 30% of small diameter axons are missing in the saphenous nerve (J:49472)

• the aortic depressor nerve is reduced in size (J:75365)

abnormal sensory neuron innervation pattern ( J:75365 )

• loss of baroreceptor innervation of the aortic arch

abnormal inner ear vestibular sensory neuron innervation pattern ( J:75365 , J:84871 )

• vestibular neurons lose target innervation in adults (J:75365)

• at P8, but not at P0, mutants show a diminished density of fibers to all canal end organs and the utricle (J:75365)

• reduction in the number of myelinated fibers extending to the posterior vertical crista at P0 and reaching 30-40% at P26-P70 (J:75365)

• defects in both afferent and efferent innervation of the vestibular sensory epithelium (J:84871)

decreased sensory neuron number ( J:75365 )

• 25% reduction of NTRK2-dependent vestibular neurons at P7 and in adulthood

small nodose ganglion ( J:49472 )

• 59% reduction in nodose neurons, primarily due to loss of NTF5 (NT4)-dependent neurons and not BDNF-dependent neurons

absent hair-down neurons ( J:49472 )

• loss of D-hair receptors

behavior/neurological

hyperactivity ( J:49472 )

hearing/vestibular/ear

abnormal inner ear vestibule morphology ( J:84871 )

• defects in both afferent and efferent innervation of the vestibular sensory epithelium

abnormal inner ear vestibular sensory neuron innervation pattern ( J:75365 , J:84871 )

• vestibular neurons lose target innervation in adults (J:75365)

• at P8, but not at P0, mutants show a diminished density of fibers to all canal end organs and the utricle (J:75365)

• reduction in the number of myelinated fibers extending to the posterior vertical crista at P0 and reaching 30-40% at P26-P70 (J:75365)

• defects in both afferent and efferent innervation of the vestibular sensory epithelium (J:84871)

Allelic Composition	Ntrk2^tm1Kln/Ntrk2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2^tm1Kln mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:210229 )

N	• no significant weight difference compared to controls is observed

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:210229 )

N	• no adrenal hypertrophy is observed

Allelic Composition	Ntrk2^tm1Bbd/Ntrk2^tm1Kln
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2^tm1Bbd mutation (2 available); any Ntrk2 mutation (66 available)
Ntrk2^tm1Kln mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:84871 )

N	• life span is normal

hearing/vestibular/ear

abnormal cochlear sensory epithelium morphology ( J:84871 )

• lack of type II nerve cells in cochlear sensory epithelium at the level of the outer hair cells

abnormal cochlear OHC afferent innervation pattern ( J:84871 )

• type II afferent fibers lacking a t birth and first post natal week in the medial and apical turns of the cochlea but they are present in the basal turn

• in adults, the pattern is reversed

abnormal type I vestibular cell ( J:84871 )

• failure of calyx like structures at the ends of afferent neurons to enclose hair cells

• innervation defects most severe in the ampullary cristae

abnormal inner ear vestibular sensory neuron innervation pattern ( J:84871 )

• defects in both afferent and efferent innervation of the vestibular sensory epithelium

increased or absent distortion product otoacoustic emission threshold ( J:84871 )

• hearing thresholds are elevated at all frequencies in heterozygotes

nervous system

abnormal cochlear OHC afferent innervation pattern ( J:84871 )

• type II afferent fibers lacking a t birth and first post natal week in the medial and apical turns of the cochlea but they are present in the basal turn

• in adults, the pattern is reversed

abnormal type I vestibular cell ( J:84871 )

• failure of calyx like structures at the ends of afferent neurons to enclose hair cells

• innervation defects most severe in the ampullary cristae

abnormal inner ear vestibular sensory neuron innervation pattern ( J:84871 )

• defects in both afferent and efferent innervation of the vestibular sensory epithelium

Allelic Composition	Ntrk2^tm1Kln/Ntrk2^tm1Kln Ntrk3^tm1Kln/Ntrk3^tm1Kln
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2^tm1Kln mutation (0 available); any Ntrk2 mutation (66 available)
Ntrk3^tm1Kln mutation (0 available); any Ntrk3 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased sensory neuron number ( J:75365 )

• 56% reduction of cochlear neurons at P70

abnormal cochlear nerve morphology ( J:75365 )

• 56% reduction in number of cochlear neurons at P70, however target innervation of the remaining cochlear neurons and hearing are normal

Allelic Composition	Bdnf^tm1Jae/Bdnf^tm2(Ntf5)Jae Ntrk2^tm1Kln/Ntrk2^tm1Kln
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm1Jae mutation (2 available); any Bdnf mutation (42 available)
Bdnf^tm2(Ntf5)Jae mutation (0 available); any Bdnf mutation (42 available)
Ntrk2^tm1Kln mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

head bobbing ( J:61340 )

hyperactivity ( J:61340 )

spinning ( J:61340 )

nervous system

decreased sensory neuron number ( J:61340 )

• observed in the vestibular, nodose-petrosal and geniculate ganglia

Allelic Composition	Bdnf^tm2(Ntf5)Jae/Bdnf^tm2(Ntf5)Jae Ntrk2^tm1Kln/Ntrk2^tm1Kln
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm2(Ntf5)Jae mutation (0 available); any Bdnf mutation (42 available)
Ntrk2^tm1Kln mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:61340 )

• episodic

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