Analysis Tools
endocrine/exocrine glands
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• glands of the nasal mucosa and maxillary sinus contain proliferating immature ductal cells and are incompletely differentiated
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• focal and often multiple poorly differentiated salivary adenocarcinomas appear in the majority of transgenics between 2 and 6 months of age
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• hyperplastic lesions of the parotid salivary glands
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• hyperplastic lesions of the sublingual salivary glands
• occasionally observe serous metaplasia in the sublingual gland
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• hyperplastic lesions of the submandibular salivary glands
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• major and minor salivary glands show severe ductular hyperplasia and incomplete differentiation
• proliferating ductules appear to consist of immature cell types
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• hyperplastic nodular lesions and multifocal neoplastic lesions at multiple sites in the fat pad of mammary glands
• mammary gland secretory lobules and alveoli are absent in parous females
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• inguinal mammary gland development is incomplete, with mutants showing a truncated version of the normal glandular penetration of the mammary fat pat and absence of end buds
• mammary gland alveolar and ductal structures are sparse
• in parous females, lobular-alveolar development is incomplete; secretory lobules and alveoli are largely missing
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• focal and often multiple poorly differentiated mammary adenocarcinomas appear in the majority of transgenics between 2 and 7 months of age
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• hyperplasia of immature ductal cells is seen frequently in the Harderian gland
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• parous females fail to lactate
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neoplasm
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• focal and often multiple poorly differentiated salivary adenocarcinomas appear in the majority of transgenics between 2 and 6 months of age
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• focal and often multiple poorly differentiated mammary adenocarcinomas appear in the majority of transgenics between 2 and 7 months of age
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• lung metastases in 4 of 7 mutants with mammary tumors
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reproductive system
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• epididymis occasionally contains reduced sperm count
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• the pseudostratified epithelium of the epididymis is disorganized
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• males exhibit severe epididymal hyperplasia
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digestive/alimentary system
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• focal and often multiple poorly differentiated salivary adenocarcinomas appear in the majority of transgenics between 2 and 6 months of age
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• hyperplastic lesions of the parotid salivary glands
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• hyperplastic lesions of the sublingual salivary glands
• occasionally observe serous metaplasia in the sublingual gland
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• hyperplastic lesions of the submandibular salivary glands
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• major and minor salivary glands show severe ductular hyperplasia and incomplete differentiation
• proliferating ductules appear to consist of immature cell types
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vision/eye
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• hyperplasia of immature ductal cells is seen frequently in the extraorbital lacrimal gland
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integument
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• hyperplastic nodular lesions and multifocal neoplastic lesions at multiple sites in the fat pad of mammary glands
• mammary gland secretory lobules and alveoli are absent in parous females
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• inguinal mammary gland development is incomplete, with mutants showing a truncated version of the normal glandular penetration of the mammary fat pat and absence of end buds
• mammary gland alveolar and ductal structures are sparse
• in parous females, lobular-alveolar development is incomplete; secretory lobules and alveoli are largely missing
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• focal and often multiple poorly differentiated mammary adenocarcinomas appear in the majority of transgenics between 2 and 7 months of age
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• parous females fail to lactate
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cellular
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• epididymis occasionally contains reduced sperm count
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growth/size/body
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• focal and often multiple poorly differentiated salivary adenocarcinomas appear in the majority of transgenics between 2 and 6 months of age
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craniofacial
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• focal and often multiple poorly differentiated salivary adenocarcinomas appear in the majority of transgenics between 2 and 6 months of age
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