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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MMTVneu)202Mul
transgene insertion 202, William Muller
MGI:1930204
Summary 20 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(CAG-Has2)99Nita/0
Tg(MMTV-cre)4Mam/0
Tg(MMTVneu)202Mul/0 		FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul MGI:4839392
cn2
 		Nmitm1.1Geno/Nmitm1.1Geno
Tg(KRT14-cre)1Amc/0
Tg(MMTVneu)202Mul/0 		involves: 129S/SvEv * C57BL/6 * CBA * FVB/N MGI:6402594
cn3
 		Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(MMTVneu)202Mul/0
Tg(S100a4-cre)1Gle/0 		involves: FVB/N MGI:4366766
cx4
 		Tg(MMTVneu)202Mul/0
Tg(Trp53R172H)8512Jmr/0 		C.FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr MGI:3799373
cx5
 		MtdhGt(XB780)Byg/MtdhGt(XB780)Byg
Tg(MMTVneu)202Mul/0 		FVB.Cg-MtdhGt(XB780)Byg Tg(MMTVneu)202Mul MGI:5661728
cx6
 		Tg(CAG-Has2)99Nita/0
Tg(MMTVneu)202Mul/0 		FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTVneu)202Mul MGI:3785872
cx7
 		Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Tg(MMTVneu)202Mul/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl * FVB/N MGI:5554380
cx8
 		Ccnd1tm1Wbg/Ccnd1+
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0 		involves: 129S2/SvPas * FVB/N MGI:5300586
cx9
 		Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0 		involves: 129S2/SvPas * FVB/N MGI:5300585
cx10
 		Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0 		involves: 129S2/SvPas * FVB/N MGI:5300587
cx11
 		Ccnd1tm1Wbg/Ccnd1+
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0 		involves: 129S2/SvPas * FVB/N MGI:5300588
cx12
 		Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0 		involves: 129S2/SvPas * FVB/N MGI:5300589
cx13
 		Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Tg(MMTVneu)202Mul/0 		involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6J * FVB/N MGI:4358063
cx14
 		Tg(MMTVneu)202Mul/0
Tg(MMTVTGFA)29Rjc/0 		involves: C57BL/6 * DBA/2 * FVB/N MGI:3800286
cx15
 		Tg(MMTV-ERBB3)1Slg/0
Tg(MMTVneu)202Mul/0 		involves: FVB MGI:2654499
cx16
 		Tg(MMTVneu)202Mul/0
Tg(Trp53R172H)8512Jmr/0 		involves: FVB MGI:3799447
cx17
 		Slc6a14tm1Gana/Slc6a14tm1Gana
Tg(MMTVneu)202Mul/0 		involves: FVB/N MGI:5807362
cx18
 		Etv4tm1Hass/Etv4tm1Hass
Tg(MMTVneu)202Mul/Tg(MMTVneu)202Mul 		involves: FVB/N MGI:3043322
tg19
 		Tg(MMTVneu)202Mul/0 FVB/N-Tg(MMTVneu)202Mul MGI:3577096
tg20
 		Tg(MMTVneu)202Mul/0 involves: FVB/N MGI:2654501


Genotype
MGI:4839392
cn1
Allelic
Composition		 Tg(CAG-Has2)99Nita/0
Tg(MMTV-cre)4Mam/0
Tg(MMTVneu)202Mul/0
Genetic
Background		 FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTV-cre)4Mam Tg(MMTVneu)202Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Has2)99Nita mutation (0 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm

hematopoietic system
impaired macrophage chemotaxis ( J:164205 )
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented
increased macrophage cell number ( J:164205 )
• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control

immune system
impaired macrophage chemotaxis ( J:164205 )
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented
increased macrophage cell number ( J:164205 )
• density of invading macrophage is 7-fold greater in the stroma of tumors compared with Neo in-control
abnormal lymphatic vessel morphology ( J:130531 )
• mammary gland tumors express more podoplanin+ lymphatic endothelial cells than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice
• intratumoral lyphatics are 16-fold greater than in Tg(MMTVneu)202Mul Tg(CAG-Has2)99Nita mice while peritumoral lymphatic vessels are only 1.5-fold greater
• tumor lymphatic vessels are associated with high hyaluronan stroma

cellular
impaired macrophage chemotaxis ( J:164205 )
• after macrophage depletion with encapsulated clodronate blood vessels in tumors were mostly small and fragmented

endocrine/exocrine glands

integument

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:164205




Genotype
MGI:6402594
cn2
Allelic
Composition		 Nmitm1.1Geno/Nmitm1.1Geno
Tg(KRT14-cre)1Amc/0
Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmitm1.1Geno mutation (0 available); any Nmi mutation (23 available)
Tg(KRT14-cre)1Amc mutation (2 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:261035 )
• shorter latency to tumor formation
• accelerated tumor growth
• higher metastasis incidence

integument
increased mammary adenocarcinoma incidence ( J:261035 )
• shorter latency to tumor formation
• accelerated tumor growth
• higher metastasis incidence

neoplasm
increased mammary adenocarcinoma incidence ( J:261035 )
• shorter latency to tumor formation
• accelerated tumor growth
• higher metastasis incidence
increased metastatic potential ( J:261035 )
• increased pulmonary metastasis by mammary tumors




Genotype
MGI:4366766
cn3
Allelic
Composition		 Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(MMTVneu)202Mul/0
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

integument
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma




Genotype
MGI:3799373
cx4
Allelic
Composition		 Tg(MMTVneu)202Mul/0
Tg(Trp53R172H)8512Jmr/0
Genetic
Background		 C.FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:115041 )
• most mice die by 11 to 12 weeks of age due to overgrowth of the poorly differentiated and invasive carcinoma and lung metastases
• all mice die prior to 18 weeks of age

neoplasm
increased parotid gland tumor incidence ( J:115041 )
• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
increased mammary adenocarcinoma incidence ( J:115041 )
• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age
increased lung tumor incidence ( J:115041 )
• mice exhibit lung metastases

endocrine/exocrine glands
increased parotid gland tumor incidence ( J:115041 )
• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
increased mammary adenocarcinoma incidence ( J:115041 )
• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age

digestive/alimentary system
increased parotid gland tumor incidence ( J:115041 )
• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice

integument
increased mammary adenocarcinoma incidence ( J:115041 )
• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age

respiratory system
increased lung tumor incidence ( J:115041 )
• mice exhibit lung metastases




Genotype
MGI:5661728
cx5
Allelic
Composition		 MtdhGt(XB780)Byg/MtdhGt(XB780)Byg
Tg(MMTVneu)202Mul/0
Genetic
Background		 FVB.Cg-MtdhGt(XB780)Byg Tg(MMTVneu)202Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MtdhGt(XB780)Byg mutation (0 available); any Mtdh mutation (33 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:214244 )
• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age
• by 18 months of age, 30% of mice are tumor free
decreased metastatic potential ( J:214244 )
• lung metastasis are severely reduced
increased tumor latency ( J:214244 )
• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age
• by 18 months of age, 30% of mice are tumor free

integument
decreased mammary gland tumor incidence ( J:214244 )
• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age
• by 18 months of age, 30% of mice are tumor free
mammary gland hyperplasia ( J:214244 )
• only 20% of mice are mildly hyperplastic while 100% of transgenic mice wild-type for Mtdh display hyperplasia at 6 months of age

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:214244 )
• by 300 days of age only 60% of mice develop tumors while almost all transgenic mice wild-type for Mtdh have tumors by this age
• by 18 months of age, 30% of mice are tumor free
mammary gland hyperplasia ( J:214244 )
• only 20% of mice are mildly hyperplastic while 100% of transgenic mice wild-type for Mtdh display hyperplasia at 6 months of age




Genotype
MGI:3785872
cx6
Allelic
Composition		 Tg(CAG-Has2)99Nita/0
Tg(MMTVneu)202Mul/0
Genetic
Background		 FVB.Cg-Tg(CAG-Has2)99Nita Tg(MMTVneu)202Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-Has2)99Nita mutation (0 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphatic vessel morphology ( J:130531 )
• intra- and inter-tumoral lymphatic vessel growth is reduced compared to in Tg(CAG-has2)99Nita Tg(MMTVneu)202Mul Tg(MMTV-cre)4Mam mice

neoplasm

endocrine/exocrine glands

integument




Genotype
MGI:5554380
cx7
Allelic
Composition		 Rasal2Gt(463C12)Cmhd/Rasal2Gt(463C12)Cmhd
Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasal2Gt(463C12)Cmhd mutation (0 available); any Rasal2 mutation (60 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice
increased metastatic potential ( J:202603 )
• increased metastasis to additional organs compared with Tg(MMTVneu)202Mul mice

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice

integument
increased mammary adenocarcinoma incidence ( J:202603 )
• at the same frequency as in Tg(MMTVneu)202Mul mice




Genotype
MGI:5300586
cx8
Allelic
Composition		 Ccnd1tm1Wbg/Ccnd1+
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days

integument
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days




Genotype
MGI:5300585
cx9
Allelic
Composition		 Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days
increased tumor latency ( J:178842 )
• development of palpable tumors in the mammary gland is delayed 3 to 4 months compared to in Ccnd1tm1Wbg/Ccnd1+ Tg(MMTV-PyVT)634Mul Tg(TetO-Ccnd1T286A)11233Kuw mice
• however, latency is the same as in Ccnd1tm1Wbg/Ccnd1tm1Wbg Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days

integument
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days




Genotype
MGI:5300587
cx10
Allelic
Composition		 Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days
increased tumor latency ( J:178842 )
• development of palpable tumors in the mammary gland is delayed 3 to 4 months compared to in Ccnd1tm1Wbg/Ccnd1+ Tg(MMTV-PyVT)634Mul Tg(TetO-Ccnd1T286A)10897Kuw mice
• however, latency is the same as in Ccnd1tm1Wbg/Ccnd1tm1Wbg Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days

integument
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 500 days




Genotype
MGI:5300588
cx11
Allelic
Composition		 Ccnd1tm1Wbg/Ccnd1+
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days

integument
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:178842 )
• in all mice by 300 days




Genotype
MGI:5300589
cx12
Allelic
Composition		 Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system




Genotype
MGI:4358063
cx13
Allelic
Composition		 Pik3cbtm1.1Ehi/Pik3cbtm1.1Ehi
Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1.1Ehi mutation (0 available); any Pik3cb mutation (152 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:152332 )
• development of first mammary tumor is delayed, number of tumors produced is decreased, and tumors growth is slower compared to in mice expression Tg(MMTVneu)202Mul alone
decreased tumor growth/size ( J:152332 )
• tumor growth is reduced compared to in mice expression Tg(MMTVneu)202Mul alone

integument
decreased mammary gland tumor incidence ( J:152332 )
• development of first mammary tumor is delayed, number of tumors produced is decreased, and tumors growth is slower compared to in mice expression Tg(MMTVneu)202Mul alone

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:152332 )
• development of first mammary tumor is delayed, number of tumors produced is decreased, and tumors growth is slower compared to in mice expression Tg(MMTVneu)202Mul alone




Genotype
MGI:3800286
cx14
Allelic
Composition		 Tg(MMTVneu)202Mul/0
Tg(MMTVTGFA)29Rjc/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
Tg(MMTVTGFA)29Rjc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland duct morphology ( J:35344 )
• female mice exhibit abnormal ductal trees
abnormal mammary gland alveolus morphology ( J:35344 )
• alveoli exhibit denser cell lining in the walls compared to Tg(MMTVTGFA)29Rjc expressing mice that exhibit cystically dilated alveoli
increased mammary gland tumor incidence ( J:35344 )
• 50% of mice exhibit mammary gland tumors at day 175 and 95% at day 250 compared to 6% of Tg(MMTVTGFA)29Rjc expressing mice and 35% of Tg(MMTVneu)202Mul expressing mice at day 250
• mice exhibit tumors that are nodular or tubular but not mixed
mammary gland hyperplasia ( J:35344 )
• nulliparous female mice exhibit epithelial hyperplasia and dysplasia along with stromal inflammation

neoplasm
increased mammary gland tumor incidence ( J:35344 )
• 50% of mice exhibit mammary gland tumors at day 175 and 95% at day 250 compared to 6% of Tg(MMTVTGFA)29Rjc expressing mice and 35% of Tg(MMTVneu)202Mul expressing mice at day 250
• mice exhibit tumors that are nodular or tubular but not mixed

behavior/neurological
abnormal nursing ( J:35344 )
• females cannot nurse her young

integument
abnormal mammary gland duct morphology ( J:35344 )
• female mice exhibit abnormal ductal trees
abnormal mammary gland alveolus morphology ( J:35344 )
• alveoli exhibit denser cell lining in the walls compared to Tg(MMTVTGFA)29Rjc expressing mice that exhibit cystically dilated alveoli
increased mammary gland tumor incidence ( J:35344 )
• 50% of mice exhibit mammary gland tumors at day 175 and 95% at day 250 compared to 6% of Tg(MMTVTGFA)29Rjc expressing mice and 35% of Tg(MMTVneu)202Mul expressing mice at day 250
• mice exhibit tumors that are nodular or tubular but not mixed
mammary gland hyperplasia ( J:35344 )
• nulliparous female mice exhibit epithelial hyperplasia and dysplasia along with stromal inflammation




Genotype
MGI:2654499
cx15
Allelic
Composition		 Tg(MMTV-ERBB3)1Slg/0
Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-ERBB3)1Slg mutation (0 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:80974 )
• 18 of 23 mice develop mammary tumors
increased incidence of tumors by chemical induction ( J:80974 )
• increased incidence (45.5%) of MNU-induced lung adenocarcinomas compared to 16% in MNU treated controls
• latency of induced tumor development is shorter than in wild-type controls or single hemizygous Tg(MMTV-ERBB3)1Slg mice
increased lung adenocarcinoma incidence ( J:80974 )
• increased incidence (30.4%) of spontaneous lung adenocarcinomas

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:80974 )
• increased incidence (45.5%) of MNU-induced lung adenocarcinomas compared to 16% in MNU treated controls
• latency of induced tumor development is shorter than in wild-type controls or single hemizygous Tg(MMTV-ERBB3)1Slg mice

respiratory system
increased lung adenocarcinoma incidence ( J:80974 )
• increased incidence (30.4%) of spontaneous lung adenocarcinomas

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:80974 )
• 18 of 23 mice develop mammary tumors

integument
increased mammary gland tumor incidence ( J:80974 )
• 18 of 23 mice develop mammary tumors




Genotype
MGI:3799447
cx16
Allelic
Composition		 Tg(MMTVneu)202Mul/0
Tg(Trp53R172H)8512Jmr/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:40336 )
• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days
• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone
• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone
• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

cellular
aneuploidy ( J:40336 )
• tumors exhibit aneuploidy and tetraploidy unlike in tumors from mice expressing Tg(MMTVneu)202Mul alone that are euploidy
polyploidy ( J:40336 )
• tumors exhibit aneuploidy and tetraploidy unlike in tumors from mice expressing Tg(MMTVneu)202Mul alone that are euploidy

integument
increased mammary gland tumor incidence ( J:40336 )
• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days
• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone
• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone
• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:40336 )
• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days
• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone
• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone
• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone




Genotype
MGI:5807362
cx17
Allelic
Composition		 Slc6a14tm1Gana/Slc6a14tm1Gana
Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a14tm1Gana mutation (0 available); any Slc6a14 mutation (13 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:226105 )
• at 10 months of age, the % of mice with palpable mammary tumors is significantly lower than that in age-matched mice carrying the transgene on a wild-type background
decreased tumor growth/size ( J:226105 )
• at 15 months of age, mice show a significant decrease in mammary tumor volume relative to age-matched mice carrying the transgene on a wild-type background
increased tumor latency ( J:226105 )
• mice develop the first palpable mammary tumor at ~500 days, i.e. significantly later than mice carrying the transgene on a wild-type background

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:226105 )
• at 10 months of age, the % of mice with palpable mammary tumors is significantly lower than that in age-matched mice carrying the transgene on a wild-type background

integument
decreased mammary gland tumor incidence ( J:226105 )
• at 10 months of age, the % of mice with palpable mammary tumors is significantly lower than that in age-matched mice carrying the transgene on a wild-type background




Genotype
MGI:3043322
cx18
Allelic
Composition		 Etv4tm1Hass/Etv4tm1Hass
Tg(MMTVneu)202Mul/Tg(MMTVneu)202Mul
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Hass mutation (1 available); any Etv4 mutation (41 available)
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:87017 )
• the onset, incidence and size of primary mammary tumors were comparable to those of Tg(MMTVneu)202Mul transgenic mice
decreased metastatic potential ( J:87017 )
• unlike mammary tumors of Tg(MMTVneu)202Mul transgenic mice, mammary tumors of mice expressing Tg(MMTVneu)202Mul in a homozygous null background did not metastasize to the lung

integument
increased mammary gland tumor incidence ( J:87017 )
• the onset, incidence and size of primary mammary tumors were comparable to those of Tg(MMTVneu)202Mul transgenic mice

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:87017 )
• the onset, incidence and size of primary mammary tumors were comparable to those of Tg(MMTVneu)202Mul transgenic mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:87017




Genotype
MGI:3577096
tg19
Allelic
Composition		 Tg(MMTVneu)202Mul/0
Genetic
Background		 FVB/N-Tg(MMTVneu)202Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary adenocarcinoma incidence ( J:56332 )
• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal
• focal adenocarcinomas surrounded by hyperplastic mammary epithelium
increased metastatic potential ( J:56332 )
• 72% of the tumor-bearing mice that lived to an age of 8 months or older developed metastases to the lung
• multiple foci of metastatic mammary adenocarcinoma lodged in pulmonary vessels were observed

integument
increased mammary adenocarcinoma incidence ( J:56332 )
• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal
• focal adenocarcinomas surrounded by hyperplastic mammary epithelium

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:56332 )
• 50% incidence observed in both virgin and non-virgin females by 205 days of age; males appear phenotypically normal
• focal adenocarcinomas surrounded by hyperplastic mammary epithelium

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:56332




Genotype
MGI:2654501
tg20
Allelic
Composition		 Tg(MMTVneu)202Mul/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:35344 , J:80974 )
• in 35% of female mice at day 250 (J:35344)

integument
increased mammary gland tumor incidence ( J:35344 , J:80974 )
• in 35% of female mice at day 250 (J:35344)

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:35344 , J:80974 )
• in 35% of female mice at day 250 (J:35344)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:80974




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory