Phenotypes associated with this allele

• Allele Symbol: Tg(K6ODCtr)55Tgo
• Allele Name: transgene insertion 55, Thomas O'Brien
• Allele ID: MGI:1930206
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(K6ODCtr)55Tgo/0 Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C3H * C57BL/6	MGI:3799500
tg2	Tg(K6ODCtr)55Tgo/0	C57BL/6-Tg(K6ODCtr)55Tgo/J	MGI:3799519
tg3	Tg(K6ODCtr)55Tgo/0	involves: C3H * C57BL/6	MGI:3799477

Genotype
MGI:3799500

cx1

• Allelic Composition: Tg(K6ODCtr)55Tgo/0; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:133302 )

N • in culture, primary keratinocytes exhibit normal life span

Genotype
MGI:3799519

tg2

• Allelic Composition: Tg(K6ODCtr)55Tgo/0
• Genetic Background: C57BL/6-Tg(K6ODCtr)55Tgo/J

adipose tissue

decreased subcutaneous adipose tissue amount ( J:62356 )

• in older mice, dermal cysts replace the subcutaneous fat layer

growth/size/body

decreased body weight ( J:62356 )

• at birth

dermal cyst ( J:62356 )

• cysts replace the lower portion of the hair follicle

• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames

• in older mice, dermal cysts replace the subcutaneous fat layer

• some cysts rupture and form foreign body granulomas

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:62356 )

• sebaceous glands are moderately hyperplastic

integument

decreased subcutaneous adipose tissue amount ( J:62356 )

• in older mice, dermal cysts replace the subcutaneous fat layer

sebaceous gland hyperplasia ( J:62356 )

• sebaceous glands are moderately hyperplastic

dermal cyst ( J:62356 )

• cysts replace the lower portion of the hair follicle

• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames

• in older mice, dermal cysts replace the subcutaneous fat layer

• some cysts rupture and form foreign body granulomas

alopecia ( J:62356 )

• by 1.5 months of age, mice exhibit generalized hair loss

• cysts replace the lower portion of the hair follicle

long nails ( J:62356 )

• mice exhibit excessive nail growth

abnormal hair follicle morphology ( J:62356 )

dilated hair follicle infundibulum ( J:62356 )

• mice exhibit a dilatation of the hair follicle infundibulum

hair follicle comedo ( J:62356 )

• mice exhibit comedo-like structures associated with sebaceous glands

hair follicle degeneration ( J:62356 )

• disintegration of the lower portion of the hair follicle

absent vibrissae ( J:62356 )

• by 1.5 months of age

wrinkled skin ( J:62356 )

• as mice age their skin exhibits excessive growth resulting in wrinkling and folding

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atrichia with papular lesions		DOID:0060689	OMIM:209500	J:62356

Genotype
MGI:3799477

tg3

• Allelic Composition: Tg(K6ODCtr)55Tgo/0
• Genetic Background: involves: C3H * C57BL/6

adipose tissue

decreased subcutaneous adipose tissue amount ( J:29098 )

• after three months of age, dermal cysts replace the subcutaneous fat layer

growth/size/body

decreased body weight ( J:29098 )

• at birth

dermal cyst ( J:29098 )

• mice exhibit follicular cysts in the dermis

• in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer

cellular

increased keratinocyte apoptosis ( J:133302 )

• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells

• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death

• however, treatment with DFMO blocks cell death in cultured primary keratinocytes

neoplasm

increased skin tumor incidence ( J:29098 )

• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice

• however, squamous cell carcinomas are not observed

increased keratoacanthoma incidence ( J:29098 )

• mice develop keratoacanthoma-like lesions

increased skin papilloma incidence ( J:29098 )

• mice develop well-differentiated papillomatous lesions

• skin tumors are found on the tail, face and ears

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:29098 )

• sebaceous glands near dermal cysts are moderately hyperplastic

integument

decreased subcutaneous adipose tissue amount ( J:29098 )

• after three months of age, dermal cysts replace the subcutaneous fat layer

increased keratinocyte apoptosis ( J:133302 )

• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells

• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death

• however, treatment with DFMO blocks cell death in cultured primary keratinocytes

sebaceous gland hyperplasia ( J:29098 )

• sebaceous glands near dermal cysts are moderately hyperplastic

dermal cyst ( J:29098 )

• mice exhibit follicular cysts in the dermis

• in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer

alopecia ( J:29098 )

• despite a normal first hair cycle, mice exhibit hair loss at 2 to 3 weeks of age

• mice exhibit complete hair loss by 2 months of age

• hair loss is a dominant phenotype

long nails ( J:29098 )

• mice exhibit excessive nail growth

absent hair follicles ( J:29098 )

• after 2 months of age

absent vibrissae ( J:29098 )

• by 2 months of age

oily skin ( J:29098 )

• develops with age

wrinkled skin ( J:29098 )

• develops with age

increased skin tumor incidence ( J:29098 )

• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice

• however, squamous cell carcinomas are not observed

increased keratoacanthoma incidence ( J:29098 )

• mice develop keratoacanthoma-like lesions

increased skin papilloma incidence ( J:29098 )

• mice develop well-differentiated papillomatous lesions

• skin tumors are found on the tail, face and ears