All Phenotypes En1<tm3(En2)Alj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

En1^tm3(En2)Alj
targeted mutation 3, Alexandra L Joyner
MGI:1930621

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	En1^tm3(En2)Alj/En1^tm3(En2)Alj	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:2175849
hm2	En1^tm3(En2)Alj/En1^tm3(En2)Alj	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	MGI:3789323
ht3	En1^tm1Alj/En1^tm3(En2)Alj	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:2175850
cx4	En1^tm2Alj/En1^tm3(En2)Alj En2^tm2Alj/En2^tm2Alj	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	MGI:3789316
cx5	En1^tm3(En2)Alj/En1^tm3(En2)Alj En2^tm2Alj/En2^tm2Alj	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	MGI:3789317
cx6	En1^tm3(En2)Alj/En1^tm3(En2)Alj En2^tm2Alj/En2⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster	MGI:3789318

Allelic Composition	En1^tm3(En2)Alj/En1^tm3(En2)Alj
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm3(En2)Alj mutation (0 available); any En1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal apical ectodermal ridge morphology ( J:34307 )

• AER is thinner than in wild-type and extends ventrally and proximally

limbs/digits/tail

abnormal limb morphology ( J:34307 )

• mice display less severe phenotype than En1^tm5(en)Alj or En1^tm1Alj homozygotes; limbs appear normal at birth but abnormalities develop postnatally

• structures (nails, digits) normally restricted to distal limb also develop proximoventrally

abnormal apical ectodermal ridge morphology ( J:34307 )

• AER is thinner than in wild-type and extends ventrally and proximally

abnormal foot pad morphology ( J:34307 )

• by 6 weeks, proximal pads develop nail-pad hybrid structures and at 3 months, on distal limbs, pad/nail hybrid structures associated with the metatarsal pads are observed

integument

abnormal nail morphology ( J:34307 )

• a few weeks after birth, ventral nails form opposite dorsal nails; in 3-month old animals, closely juxtaposed ventral and dorsal nails (cylindrical nails) are observed on the distal limbs

Allelic Composition	En1^tm3(En2)Alj/En1^tm3(En2)Alj
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm3(En2)Alj mutation (0 available); any En1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:134516 )

N	• cerebellum and colliculi have normal morphology at E18.5

Allelic Composition	En1^tm1Alj/En1^tm3(En2)Alj
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (34 available)
En1^tm3(En2)Alj mutation (0 available); any En1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:27767 )

• brain, limbs, and sternum normal

Allelic Composition	En1^tm2Alj/En1^tm3(En2)Alj En2^tm2Alj/En2^tm2Alj
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2Alj mutation (1 available); any En1 mutation (34 available)
En1^tm3(En2)Alj mutation (0 available); any En1 mutation (34 available)
En2^tm2Alj mutation (0 available); any En2 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased inferior colliculus size ( J:134516 )

• reduced in size at E18.5

abnormal cerebellum morphology ( J:134516 )

• in posterior hemisphere crusil and paramedian folia are fused; in one embryo, a partial fissure separating crusil and paramedian folia is observed

abnormal cerebellar foliation ( J:134516 )

• foliation defects are milder than in En1^tm2Alj /+, En2^tm2Alj homozygotes; most mutants have foliation pattern similar to hemispheres of En2^tm2Alj homozygotes

abnormal cerebellum posterior vermis morphology ( J:134516 )

• subregion VIII (posterior vermis) is not present at E18.5

small cerebellum ( J:134516 )

• at E18.5, reduced in overall size by one-third relative to controls

Allelic Composition	En1^tm3(En2)Alj/En1^tm3(En2)Alj En2^tm2Alj/En2^tm2Alj
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm3(En2)Alj mutation (0 available); any En1 mutation (34 available)
En2^tm2Alj mutation (0 available); any En2 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:134516 )

N	• mice are viable into adulthood

nervous system

abnormal cerebellum morphology ( J:134516 )

• in posterior hemisphere crusil and paramedian folia are fused

abnormal cerebellar foliation ( J:134516 )

• in a small number of mutants, folium VIII is abnormal, being associated with folium IX

small cerebellum ( J:134516 )

• at E18.5, reduced in overall size by one-third relative to controls

Allelic Composition	En1^tm3(En2)Alj/En1^tm3(En2)Alj En2^tm2Alj/En2⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:134516 )

N	• cerebellum and colliculi have normal morphology at E18.5

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