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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat1tm1Dlv
targeted mutation 1, David E Levy
MGI:1930947
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat1tm1Dlv/Stat1tm1Dlv B6.129S-Stat1tm1Dlv MGI:3813923
hm2
 		Stat1tm1Dlv/Stat1tm1Dlv B6.129-Stat1tm1Dlv MGI:2654513
hm3
 		Stat1tm1Dlv/Stat1tm1Dlv either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1) MGI:2653179
hm4
 		Stat1tm1Dlv/Stat1tm1Dlv involves: 129S/SvEv MGI:3806318
cx5
 		Col1a1tm1(tetO-Stat1)Biat/Col1a1tm1(tetO-Stat1)Biat
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Stat1tm1Dlv/Stat1tm1Dlv 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 MGI:5698051
cx6
 		Stat1tm1Dlv/Stat1tm1Dlv
Tg(ANPEP)270Mmul/Tg(ANPEP)270Mmul 		involves: 129S/SvEv * ICR MGI:6403902
cx7
 		Stat1tm1Dlv/Stat1tm1Dlv
Tg(ANPEP)861Mmul/Tg(ANPEP)861Mmul 		involves: 129S/SvEv * ICR MGI:6403905


Genotype
MGI:3813923
hm1
Allelic
Composition		 Stat1tm1Dlv/Stat1tm1Dlv
Genetic
Background		 B6.129S-Stat1tm1Dlv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:79552 )
• proportions of spleen NK cells expressing intracellular IFN-gamma from MCMV infected mice are increased
• there is 75% less actively proliferating NK cells in the spleen after MCMV infection compared to controls
• NK cells have less proliferation in response to IFN-alpha treatment compared to controls and thus do not have the 2- to 6-fold gains in liver NK cell numbers that wild-type controls do
impaired natural killer cell mediated cytotoxicity ( J:79552 )
• NK cells from MCMV-infected mice have about 3-fold less cytotoxicity than wild-type NK cells
• NK cells fail to increase their cytolytic activity when treated with recombinant IFN-alpha
increased circulating interferon-gamma level ( J:79552 )
• serum IFN-gamma levels are 6-fold higher than controls in mice infected with MCMV
increased circulating interleukin-12b level ( J:79552 )
• mice infected with LCMV have 5-fold higher levels of IL-12 p40 than in controls

endocrine/exocrine glands
increased mammary adenocarcinoma incidence ( J:216040 )
• mice develop spontaneous mammary adenocarcinoma with a median tumor onset of 14.5 months

homeostasis/metabolism
increased circulating interferon-gamma level ( J:79552 )
• serum IFN-gamma levels are 6-fold higher than controls in mice infected with MCMV
increased circulating interleukin-12b level ( J:79552 )
• mice infected with LCMV have 5-fold higher levels of IL-12 p40 than in controls

integument
increased mammary adenocarcinoma incidence ( J:216040 )
• mice develop spontaneous mammary adenocarcinoma with a median tumor onset of 14.5 months

hematopoietic system
abnormal NK cell physiology ( J:79552 )
• proportions of spleen NK cells expressing intracellular IFN-gamma from MCMV infected mice are increased
• there is 75% less actively proliferating NK cells in the spleen after MCMV infection compared to controls
• NK cells have less proliferation in response to IFN-alpha treatment compared to controls and thus do not have the 2- to 6-fold gains in liver NK cell numbers that wild-type controls do
impaired natural killer cell mediated cytotoxicity ( J:79552 )
• NK cells from MCMV-infected mice have about 3-fold less cytotoxicity than wild-type NK cells
• NK cells fail to increase their cytolytic activity when treated with recombinant IFN-alpha

neoplasm
increased mammary adenocarcinoma incidence ( J:216040 )
• mice develop spontaneous mammary adenocarcinoma with a median tumor onset of 14.5 months




Genotype
MGI:2654513
hm2
Allelic
Composition		 Stat1tm1Dlv/Stat1tm1Dlv
Genetic
Background		 B6.129-Stat1tm1Dlv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Herpesvirales infection ( J:81243 )
• slighty more susceptible to MCMV viral infection than wild-type
increased susceptibility to Togaviridae infection ( J:81243 )
• slighty more susceptible to Sindbis viral infection than wild-type




Genotype
MGI:2653179
hm3
Allelic
Composition		 Stat1tm1Dlv/Stat1tm1Dlv
Genetic
Background		 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, complete penetrance ( J:31325 )
• mice fail to thrive, with death occurring withing 48 hours of weaning

digestive/alimentary system
abnormal intestine morphology ( J:31325 )
• intestinal lesions of necrotic foci with syncytial giant cells at necroscopy, incomplete penetrance

growth/size/body
decreased body size ( J:31325 )

immune system
abnormal leukocyte physiology ( J:31325 )
• splenocytes and macrophages failed to respond transcriptionally after exposure to IFN-gamma
increased susceptibility to Riboviria infection ( J:31325 )
• observed when exposed to vesicular stomatitis virus (VSV) under specific pathogen-free conditions
increased susceptibility to Coronaviridae infection ( J:31325 )
• observed in conventional facility, where mouse hepatitis virus was common

liver/biliary system
multifocal hepatic necrosis ( J:31325 )
• with syncytial cell formation at necroscopy

hematopoietic system
abnormal leukocyte physiology ( J:31325 )
• splenocytes and macrophages failed to respond transcriptionally after exposure to IFN-gamma




Genotype
MGI:3806318
hm4
Allelic
Composition		 Stat1tm1Dlv/Stat1tm1Dlv
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:99728 )
N
• mice are not susceptible to infection with an adapted human coronavirus 229E (HCoV-229E) that was produced by propagating the virus for 4 passages at 37 degrees Celsius on primary embryonic fibroblasts (HCoV-229E-37), showing no virus growth in lung, liver, spleen or small intestine
abnormal MHC II cell surface expression on macrophages ( J:130622 )
• unstimulated bone marrow derived macrophages have much lower expression of class II on cell surface
increased circulating interferon-gamma level ( J:130622 )
• LPS administration leads to about 10-fold higher levels of IFN-gamma in the sera of mice compared to wild-type mice treated with LPS
decreased level of surface class I molecules ( J:130622 )
• unstimulated bone marrow derived macrophages have lower expression of class I on the cell surface
decreased susceptibility to endotoxin shock ( J:130622 )
• no mice die of LPS at a dose of 37 mg/kg body weight compared to 80% of Stat1tm1Tdec homozygotes dying at this dose
increased susceptibility to bacterial infection ( J:130622 )
• mice all die when infected with 104 or higher Listeria monocytogenes bacteria while all wild-type mice survive
increased susceptibility to Riboviria infection ( J:130622 )
• primary fibroblasts pre-treated with IFN-gamma and then exposed to vesicular stomatitis virus are all dead 24 hours later regardless of the amount of IFN-gamma used

homeostasis/metabolism
increased circulating interferon-gamma level ( J:130622 )
• LPS administration leads to about 10-fold higher levels of IFN-gamma in the sera of mice compared to wild-type mice treated with LPS

vision/eye
vision/eye phenotype ( J:88422 )
N
• lens development is normal

hematopoietic system
abnormal MHC II cell surface expression on macrophages ( J:130622 )
• unstimulated bone marrow derived macrophages have much lower expression of class II on cell surface




Genotype
MGI:5698051
cx5
Allelic
Composition		 Col1a1tm1(tetO-Stat1)Biat/Col1a1tm1(tetO-Stat1)Biat
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Stat1tm1Dlv/Stat1tm1Dlv
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Stat1)Biat mutation (1 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (993 available)
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
abnormal susceptibility to infection induced morbidity/mortality ( J:212694 )
• Vesicular Stomatitis Virus or Encephalomyocarditis Virus infection results in death
• mice treated with doxycycline prior to viral infection survive at rates only slightly lower than wild-type controls

immune system
abnormal susceptibility to infection induced morbidity/mortality ( J:212694 )
• Vesicular Stomatitis Virus or Encephalomyocarditis Virus infection results in death
• mice treated with doxycycline prior to viral infection survive at rates only slightly lower than wild-type controls




Genotype
MGI:6403902
cx6
Allelic
Composition		 Stat1tm1Dlv/Stat1tm1Dlv
Tg(ANPEP)270Mmul/Tg(ANPEP)270Mmul
Genetic
Background		 involves: 129S/SvEv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (74 available)
Tg(ANPEP)270Mmul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Coronaviridae infection ( J:99728 )
• mice inoculated through oral, intranasal, intragastic and intraperitoneal routes with an adapted human coronavirus 229E (HCoV-229E) that was produced by propagating the virus for 4 passages at 37 degrees Celsius on primary embryonic fibroblasts (HCoV-229E-37) are permissive to infection, showing large amounts of virus in the lungs and the gut, and also in the spleen and liver, with mice surviving at least 18 days after infection, showing a mild loss of weight and slight temperature increase, and hemorrhaging areas in lung and small intestines
• mice administered HCoV-229E-37 through the nasal route show virus growth in the lung but not in the gut, liver or spleen

cardiovascular system
internal hemorrhage ( J:99728 )
• mice challenged with HCoV-229E-37 by the different routes show hemorrhaging areas in lung and small intestine, mainly between 2 and 4 days post infection

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:99728




Genotype
MGI:6403905
cx7
Allelic
Composition		 Stat1tm1Dlv/Stat1tm1Dlv
Tg(ANPEP)861Mmul/Tg(ANPEP)861Mmul
Genetic
Background		 involves: 129S/SvEv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (74 available)
Tg(ANPEP)861Mmul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Coronaviridae infection ( J:99728 )
• mice inoculated through oral, intranasal, intragastic and intraperitoneal routes with an adapted human coronavirus 229E (HCoV-229E) that was produced by propagating the virus for 4 passages at 37 degrees Celsius on primary embryonic fibroblasts (HCoV-229E-37) are permissive to infection, showing large amounts of virus in the lungs and the gut, and also in the spleen and liver, with mice surviving at least 18 days after infection, showing a mild loss of weight and slight temperature increase, and hemorrhaging areas in lung and small intestines
• mice administered HCoV-229E-37 through the nasal rout show virus growth in the lung but not in the gut, liver or spleen

cardiovascular system
lung hemorrhage ( J:99728 )
• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the lung, mainly between 2 and 4 days post infection
small intestine hemorrhage ( J:99728 )
• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the small intestine, mainly between 2 and 4 days post infection

respiratory system
lung hemorrhage ( J:99728 )
• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the lung, mainly between 2 and 4 days post infection

digestive/alimentary system
small intestine hemorrhage ( J:99728 )
• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the small intestine, mainly between 2 and 4 days post infection

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:99728




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory