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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ifngr2tm1Pbro
targeted mutation 1, Paul B Rothman
MGI:1930965
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ifngr2tm1Pbro/Ifngr2tm1Pbro involves: 129S1/Sv MGI:3603844
hm2
 		Ifngr2tm1Pbro/Ifngr2tm1Pbro NOD.129S1-Ifngr2tm1Pbro MGI:3603845


Genotype
MGI:3603844
hm1
Allelic
Composition		 Ifngr2tm1Pbro/Ifngr2tm1Pbro
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr2tm1Pbro mutation (2 available); any Ifngr2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:48016 )
• class switching to IgG2a inhibited when stimulated with IFN-gamma
• class switching to IgE and IgG1 caused by Il-4 fails
abnormal T-helper 1 cell differentiation ( J:48016 )
• differentiation of Th1 cells inhibited
increased susceptibility to bacterial infection ( J:48016 )
• increased susceptibility to Listeria monocytogenes infection

hematopoietic system
abnormal class switch recombination ( J:48016 )
• class switching to IgG2a inhibited when stimulated with IFN-gamma
• class switching to IgE and IgG1 caused by Il-4 fails
abnormal T-helper 1 cell differentiation ( J:48016 )
• differentiation of Th1 cells inhibited




Genotype
MGI:3603845
hm2
Allelic
Composition		 Ifngr2tm1Pbro/Ifngr2tm1Pbro
Genetic
Background		 NOD.129S1-Ifngr2tm1Pbro
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr2tm1Pbro mutation (2 available); any Ifngr2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal diapedesis ( J:72818 )
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

immune system
abnormal diapedesis ( J:72818 )
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis
abnormal T-helper 2 physiology ( J:65986 )
• enhanced Th2 responses
abnormal cytotoxic T cell physiology ( J:72818 )
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis
decreased susceptibility to autoimmune diabetes ( J:72818 )
• when diabetogenic splenocytes are injected into Ifngr2-deficient NOD mice, diabetes development is delayed compared to wild-type NOD mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:65986 )
N
• unexpectedly, incidence of type 1 diabetes in females was unchanged

hematopoietic system
abnormal diapedesis ( J:72818 )
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis
abnormal T-helper 2 physiology ( J:65986 )
• enhanced Th2 responses
abnormal cytotoxic T cell physiology ( J:72818 )
• CD8+ T cells injected into Ifngr2-deficient NOD mice are less able to cause diabetes, due to impaired homing ability and impaired diapedesis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:72818




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory