Phenotypes associated with this allele

• Allele Symbol: Agrn^tm3Jrs
• Allele Name: targeted mutation 3, Joshua R Sanes
• Allele ID: MGI:1930979
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agrn^tm3Jrs/Agrn^tm3Jrs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716824

Genotype
MGI:3716824

hm1

• Allelic Composition: Agrn^tm3Jrs/Agrn^tm3Jrs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:55407 )

• homozygotes are stillborn or die immediately after birth

nervous system

abnormal innervation ( J:55407 )

• an intramuscular nerve forms and axons leave the nerve, but fail to stop and arborize, instead axons run parallel to myotubes for long distances

abnormal neuromuscular synapse morphology ( J:55407 )

• acetylcholine receptor (AChR) clusters are fewer in number, ~30% smaller in size and lower in density; two thirds of AChR clusters are not opposed by neurites and many clusters are outside the end plate band

behavior/neurological

no spontaneous movement ( J:55407 )

• neonates are never seen to move spontaneously

respiratory system

primary atelectasis ( J:55407 )

• neonates do not inflate their lungs