Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mlh1tm1Mse targeted mutation 1, Mutsuo Sekiguchi MGI:1930998 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit increased spontaneous tumurogenesis compared to wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 70% of methylnitrosourea mice exhibit thymic lymphomas that increase the weight of the thymus by up to 10 times unlike wild-type mice that do not develop lymphomas in response to methylnitrosourea treatment
• in half of the affected mice, lymphomas infiltrate other organs
|
|
• in 2 methylnitrosourea-treated mice
|
|
• 70% of methylnitrosourea mice exhibit thymic lymphomas that increase the weight of the thymus by up to 10 times unlike wild-type mice that do not develop lymphomas in response to methylnitrosourea treatment
• in half of the affected mice, lymphomas infiltrate other organs
|
| N |
• unlike Mgmttm1Mse homozygotes, mice exhibit normal resistance to methylnitrosourea treatment
|
|
• in 2 methylnitrosourea-treated mice
|
|
• 70% of methylnitrosourea mice exhibit thymic lymphomas that increase the weight of the thymus by up to 10 times unlike wild-type mice that do not develop lymphomas in response to methylnitrosourea treatment
• in half of the affected mice, lymphomas infiltrate other organs
|
|
• 70% of methylnitrosourea mice exhibit thymic lymphomas that increase the weight of the thymus by up to 10 times unlike wild-type mice that do not develop lymphomas in response to methylnitrosourea treatment
• in half of the affected mice, lymphomas infiltrate other organs
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
