Phenotypes associated with this allele

• Allele Symbol: Rb1^tm1Brn
• Allele Name: targeted mutation 1, Anton Berns
• Allele ID: MGI:1931015
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rb1^tm1Brn/Rb1^tm1Brn	involves: 129P2/OlaHsd * FVB/N	MGI:4353086
cn2	Rb1^tm1Brn/Rb1^tm1Brn Tg(Pomc-FLP)1aBrn/0	involves: 129P2/OlaHsd * FVB/N	MGI:4353102
cn3	Rb1^tm1Brn/Rb1^+ Tg(Pomc-FLP)1aBrn/0	involves: 129P2/OlaHsd * FVB/N	MGI:4353103
cn4	Rb1^tm1Brn/Rb1^tm1Brn X/Tg(Pomc-FLP)1bBrn	involves: 129P2/OlaHsd * FVB/N	MGI:4353104
cn5	Rb1^tm1Brn/Rb1^+ X/Tg(Pomc-FLP)1bBrn	involves: 129P2/OlaHsd * FVB/N	MGI:4353105

Genotype
MGI:4353086

hm1

• Allelic Composition: Rb1^tm1Brn/Rb1^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:48860 )

• mice exhibit no signs of disease and essentially behave as wild-type mice

Genotype
MGI:4353102

cn2

• Allelic Composition: Rb1^tm1Brn/Rb1^tm1Brn; Tg(Pomc-FLP)1aBrn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

mortality/aging

premature death ( J:48860 )

• all mice die within 20 weeks (or 5 months)

neoplasm

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

nervous system

increased pituitary adenoma incidence ( J:48860 )

• at 12 weeks, mice develop pituitary adenomas to which they succumb within 20 weeks of age

• the average latency of tumors is 4 months and all mice die within 5 months

• tumors exhibit hyperproliferation and apoptosis is reduced in end-stage tumors

Genotype
MGI:4353103

cn3

• Allelic Composition: Rb1^tm1Brn/Rb1⁺; Tg(Pomc-FLP)1aBrn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

nervous system

abnormal pituitary intermediate lobe morphology ( J:48860 )

• at 6 and 12 weeks, mice exhibit atypical lesions in the intermediate lobe of the pituitary gland unlike in Rb1^tm1Brn homozygotes

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

neoplasm

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

endocrine/exocrine glands

abnormal pituitary intermediate lobe morphology ( J:48860 )

• at 6 and 12 weeks, mice exhibit atypical lesions in the intermediate lobe of the pituitary gland unlike in Rb1^tm1Brn homozygotes

increased pituitary adenoma incidence ( J:48860 )

• mice develop pituitary adenomas with an average latency of 9 months

• tumors exhibit hyperproliferation

Genotype
MGI:4353104

cn4

• Allelic Composition: Rb1^tm1Brn/Rb1^tm1Brn; X/Tg(Pomc-FLP)1bBrn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

mortality/aging

decreased tumor-free survival time ( J:48860 )

♂ • mice die of tumors within 11 months

nervous system

pituitary intermediate lobe hyperplasia ( J:48860 )

♂ • at 6 and 12 weeks, mice exhibit extensive hyperplasia with areas of more densely packed cells with nodular appearance unlike in wild-type mice

♂ • at 12 weeks, the cell mass of the intermediate lobe is increased with a 2.5-fold higher cell density of hyperplastic areas and nodules compared to in wild-type mice

increased pituitary adenoma incidence ( J:48860 )

♂ • mice develop pituitary adenomas at a slower rate than in Rb1^tm1Brn/ Rb1^tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months

♂ • tumors exhibit hyperproliferation

neoplasm

increased pituitary adenoma incidence ( J:48860 )

♂ • mice develop pituitary adenomas at a slower rate than in Rb1^tm1Brn/ Rb1^tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months

♂ • tumors exhibit hyperproliferation

endocrine/exocrine glands

pituitary intermediate lobe hyperplasia ( J:48860 )

♂ • at 6 and 12 weeks, mice exhibit extensive hyperplasia with areas of more densely packed cells with nodular appearance unlike in wild-type mice

♂ • at 12 weeks, the cell mass of the intermediate lobe is increased with a 2.5-fold higher cell density of hyperplastic areas and nodules compared to in wild-type mice

increased pituitary adenoma incidence ( J:48860 )

♂ • mice develop pituitary adenomas at a slower rate than in Rb1^tm1Brn/ Rb1^tm1Brn Tg(Pomc-Flp)1aBrn mice with an average latency of 7 months

♂ • tumors exhibit hyperproliferation

Genotype
MGI:4353105

cn5

• Allelic Composition: Rb1^tm1Brn/Rb1⁺; X/Tg(Pomc-FLP)1bBrn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

endocrine/exocrine glands

pituitary intermediate lobe hyperplasia ( J:48860 )

♂ • at 12 weeks in some mice

nervous system

pituitary intermediate lobe hyperplasia ( J:48860 )

♂ • at 12 weeks in some mice