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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vegfatm1Dco
targeted mutation 1, Desire Collen
MGI:1931046
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vegfatm1Dco/Vegfatm1Dco involves: 129 MGI:3849560
ht2
 		Vegfatm1Dco/Vegfa+ involves: 129 MGI:3849561


Genotype
MGI:3849560
hm1
Allelic
Composition		 Vegfatm1Dco/Vegfatm1Dco
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfatm1Dco mutation (0 available); any Vegfa mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:32219 )
• no viable mice are obtained at birth

cardiovascular system
abnormal vascular development ( J:32219 )
• at E9.5, vascular structures are enlarged in the anterior part of the embryo
abnormal dorsal aorta morphology ( J:32219 )
• at E8.5, the dorsal aorta is absent in the anterior part of the embryo
abnormal vascular endothelial cell differentiation ( J:32219 )
• endothelial cell development is delayed compared to in wild-type mice

cellular
abnormal vascular endothelial cell differentiation ( J:32219 )
• endothelial cell development is delayed compared to in wild-type mice




Genotype
MGI:3849561
ht2
Allelic
Composition		 Vegfatm1Dco/Vegfa+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfatm1Dco mutation (0 available); any Vegfa mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal dorsal aorta morphology ( J:32219 )
• the dorsal aorta has a smaller lumen and fewer endothelial cells than in wild-type mice
• at E9.5, the anterior part of the dorsal aorta is poorly developed
decreased angiogenesis ( J:32219 )
• the density of sprouting intersomitic and head mesenchyme vessels is decreased compared to in wild-type mice
abnormal vitelline vasculature morphology ( J:32219 )
• at E9.5, yolk sacs display an irregular plexus of small vessels with no larger collecting vessels unlike in wild-type mice
• however, endothelial cell density and proliferation rates are normal

embryo
abnormal vitelline vasculature morphology ( J:32219 )
• at E9.5, yolk sacs display an irregular plexus of small vessels with no larger collecting vessels unlike in wild-type mice
• however, endothelial cell density and proliferation rates are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory