Phenotypes associated with this allele

• Allele Symbol: Lpar1^tm1Jch
• Allele Name: targeted mutation 1, Jerod Chun
• Allele ID: MGI:1931154
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lpar1^tm1Jch/Lpar1^tm1Jch	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2171671

Genotype
MGI:2171671

hm1

• Allelic Composition: Lpar1^tm1Jch/Lpar1^tm1Jch
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gross abnormalities in Lpar1^tm1Jch/Lpar1^tm1Jch mice

mortality/aging

neonatal lethality, incomplete penetrance ( J:65882 )

• approximately 15% die shortly after birth

postnatal lethality, incomplete penetrance ( J:65882 )

• approximately 35% die before 3 weeks of age

behavior/neurological

abnormal suckling behavior ( J:65882 )

• pups exhibited either no suckling behavior or impaired suckling behavior; normal rooting behavior was noted; authors postulate that defects in olfaction detection or processing resulted in this phenotype

craniofacial

short snout ( J:65882 )

growth/size/body

short snout ( J:65882 )

decreased body size ( J:65882 )

• juveniles and adults are smaller

postnatal growth retardation ( J:65882 )

• 30% reduction in size of animals surviving birth relative to control siblings

vision/eye

ocular hypertelorism ( J:65882 )

• widely spaced eyes

nervous system

abnormal Schwann cell morphology ( J:65882 )

• increase in apoptosis of Schwann cells in the Sciatic nerve (18% versus 10% in wild-type)

decreased Schwann cell number ( J:65882 )

exencephaly ( J:65882 )

• observed in 3 of 61 mice

abnormal sciatic nerve morphology ( J:65882 )

• increase in apoptosis in the sciatic nerve

cardiovascular system

hemorrhage ( J:65882 )

• 4 of 160 embryos and neonates exhibit frontal cranial hemorrhage

adipose tissue

decreased total body fat amount ( J:65882 )

• lower relataive amounts of fat