All Phenotypes Il6st<tm1Wme> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il6st^tm1Wme/Il6st^tm1Wme	involves: 129P2/OlaHsd * C57BL/6	MGI:3623207
cn2	Il6st^tm1Ern/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/?	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N	MGI:3837205
cn3	Il6st^tm1Ard/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/?	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N	MGI:3837204
cn4	Il6st^tm1Wme/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:3837311

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart development ( J:67677 )

abnormal heart ventricle morphology ( J:67677 )

• a subpopulation of cardiomyocytes located here have reduced diameter

hematopoietic system

decreased thymocyte number ( J:67677 )

• the T-cell population is reduced by 30%

abnormal erythropoiesis ( J:67677 )

• resynthesis of erythrocytes is impaired after mice are treated with 5-fluoro-5'-deoxyuridine

abnormal T cell differentiation ( J:67677 )

abnormal thrombopoiesis ( J:67677 )

• there is a reduced thrombocyte count in the peripheral blood

• resynthesis of thrombocytes is impaired after mice are treated with 5-fluoro-5'-deoxyuridine

increased leukocyte cell number ( J:67677 )

• there is an increased number of circulating leukocytes

abnormal immunoglobulin level ( J:67677 )

• there is an increase in the circulating level of IgG1

• there is an increase in the circulating level of IgE

increased IgE level ( J:67677 )

increased IgG level ( J:67677 )

immune system

decreased thymocyte number ( J:67677 )

• the T-cell population is reduced by 30%

abnormal T cell differentiation ( J:67677 )

abnormal thrombopoiesis ( J:67677 )

• there is a reduced thrombocyte count in the peripheral blood

• resynthesis of thrombocytes is impaired after mice are treated with 5-fluoro-5'-deoxyuridine

increased leukocyte cell number ( J:67677 )

• there is an increased number of circulating leukocytes

abnormal immunoglobulin level ( J:67677 )

• there is an increase in the circulating level of IgG1

• there is an increase in the circulating level of IgE

increased IgE level ( J:67677 )

increased IgG level ( J:67677 )

nervous system

abnormal Schwann cell morphology ( J:67677 )

• in myocardium and gut incomplete Schwann cell covering of small and thick bundles noted

abnormal myelination ( J:67677 )

• range of defects are noted from loss of laminar structure to loss of myelin sheath and axon lysis

endocrine/exocrine glands

decreased thymocyte number ( J:67677 )

• the T-cell population is reduced by 30%

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Il6st^tm1Wme mutation (2 available); any Il6st mutation (80 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:97327 )

N	• do not suffer liver damage from ConA treatment if pretreated with Il6

abnormal liver regeneration ( J:135290 )

• maximal DNA synthesis in hepatocytes after partial hepatectomy occurs after about 48 hours

• hepatocyte growth factor has no effect on hepatocyte proliferation unless administered with Il6

Allelic Composition	Il6st^tm1Ard/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ard mutation (2 available); any Il6st mutation (80 available)
Il6st^tm1Wme mutation (2 available); any Il6st mutation (80 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:97327 )

• die within 8 hours of ConA treatment regardless of pretreatment with Il6

liver/biliary system

abnormal liver physiology ( J:97327 )

• liver damage due to ConA treatment regardless of pretreatment with Il6

abnormal liver regeneration ( J:135290 )

• maximal DNA synthesis in hepatocytes after partial hepatectomy and lipopolysaccharide treatment is reduced relative to controls

• 20% of cells as compared to 30% of cells

Allelic Composition	Il6st^tm1Wme/Il6st^tm1Wme Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Wme mutation (2 available); any Il6st mutation (80 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal liver regeneration ( J:135290 )

• maximal DNA synthesis in hepatocytes after partial hepatectomy and lipopolysaccharide treatment is reduced relative to controls

• 10% of cells as compared to 30% of cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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