All Phenotypes Nr3c1<tm2Gsc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr3c1^tm2Gsc
targeted mutation 2, Gunther Schutz
MGI:1931327

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Lyz2^tm1(cre)Ifo/Lyz2⁺	B6.129P2-Lyz2^tm1(cre)Ifo Nr3c1^tm2Gsc	MGI:3817871
cn2	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm/0	B6.Cg-Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm	MGI:3817872
cn3	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Lyz2^tm1(cre)Ifo/Lyz2⁺	C.129P2-Lyz2^tm1(cre)Ifo Nr3c1^tm2Gsc	MGI:4455049
cn4	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N	MGI:4840248
cn5	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N	MGI:4840249
cn6	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Drd1a-cre)AGsc/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3852119
cn7	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Slc6a3-icre)1Fto/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3852116
cn8	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6J * SJL	MGI:2176972
cn9	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3852117
cn10	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Wap-cre)1Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:3527493
cn11	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Camk2a-cre/ERT2)2Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:3759306
cn12	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Runx2-icre)1Jtuc/0	involves: 129P2/OlaHsd * FVB/N	MGI:4455043
cn13	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Alb1-cre)7Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:4840245

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	B6.129P2-Lyz2^tm1(cre)Ifo Nr3c1^tm2Gsc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:137157 )

N	• mice exhibit normal susceptibility to MOG induced experimental autoimmune encephalomyelitis and response to treatment with dexamethasone

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm/0
Genetic Background	B6.Cg-Nr3c1^tm2Gsc Tg(Lck-cre)I57Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell apoptosis ( J:137157 )

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

increased susceptibility to experimental autoimmune encephalomyelitis ( J:137157 )

• following exposure to MOG, mice exhibit earlier induction of experimental autoimmune encephalomyelitis than in similarly treated wild-type mice and fail to recover after treatment with dexamethasone as do Nr3c1^tm2Gsc control mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:137157 )

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

• following induction of experimental autoimmune encephalomyelitis and treatment with dexamethasone, regulatory T cell numbers are not as diminished as in Nr3c1^tm2Gsc control mice and expression of Foxp3 is unaltered

• unlike in peripheral T cells from Nr3c1^tm2Gsc control mice, treatment with dexamethasone does not reduced expression of cell adhesion molecules

cellular

decreased T cell apoptosis ( J:137157 )

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

hematopoietic system

decreased T cell apoptosis ( J:137157 )

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	C.129P2-Lyz2^tm1(cre)Ifo Nr3c1^tm2Gsc

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:160669 )

N	• bone formation rate with prednisolone treatment for 2 weeks is reduced in mutants and controls

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:121556 )

• reduced body weight starting around 3 weeks of age

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:121556 )

• reduced body weight starting around 3 weeks of age

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Drd1a-cre)AGsc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Drd1a-cre)AGsc mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:150544 )

N	• Anxiety-related behavior, basic motor processes (movement, coordination), and associative learning are not impaired in mutants

abnormal behavioral response to addictive substance ( J:150544 )

• mice show profoundly decreased cocaine self-administration; acquistion of cocaine self-administration is similar to controls but dose-response is decreased indicating a lower reinforcing efficacy of cocaine

nervous system

abnormal nervous system electrophysiology ( J:150544 )

• spontaneous firing rate of dopamine neurons is highly reduced in ventral tegmental area (VTA)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150544 )

N	• circulating glucocorticoid levels are normal under basal and stress conditions • anxiety-related behaviors are not altered compared to controls indicating behavioral changes are specific to cocaine reinforcement

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Slc6a3-icre)1Fto/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Slc6a3-icre)1Fto mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:150544 )

N	• mutant and control mice show similar acquisition and motivation to self-administer cocaine

nervous system

nervous system phenotype ( J:150544 )

N	• spontaneous activity (firing rates) of dopamine neurons in the ventral tegmental area (VTA) is similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150544 )

N	• circulating glucocorticoid levels are normal under basal and stress conditions

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal fear/anxiety-related behavior ( J:57315 )

• impaired stress response in Porsolt forced-swim test; mice show normal immobility scores in an initial test, but do not show an increased response in a 24-hour restest

decreased anxiety-related response ( J:57315 )

• in a light-dark crossing task test, mice exhibit a reduced latentcy in entering an aversive bright compartment and spent more time there

• in a zero-maze test, mice demonstrated an increased number of entries into the averse open segment and spent more time there

growth/size/body

decreased body size ( J:57315 )

decreased body weight ( J:57315 )

• mice are 70+/-3% of the weight of control mice at 6-14 weeks of age

decreased body length ( J:57315 )

• mice are 82+/-0.4% of the length of control mice at 6-14 weeks of age

skeleton

decreased bone mineral density ( J:57315 )

• bone density is reduced in the skull and pelvis bones

osteoporosis ( J:57315 )

adipose tissue

abnormal adipose tissue distribution ( J:57315 )

• a displacement of fat tissue towards the head and neck from the rest of the body is apparent

• mice are not obese

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:57315 )

N	• the morphology of the adrenal glands is similar to controls • levels of adrenaline and noradrenaline in the adrenal glands is similar to controls

homeostasis/metabolism

increased circulating glucocorticoid level ( J:57315 )

• morning levels of circulating glucocorticoids are elevated

• normal circadian rhythm is maintained

decreased circulating adrenocorticotropin level ( J:57315 )

• plasma levels of ACTH are moderately reduced

increased adrenocorticotropin level ( J:57315 )

• in the anterior pituitary, an increase in the level of ACTH and its transcript levels are seen

nervous system

hypersecretion of corticotropin-releasing hormone ( J:57315 )

• elevation of CRH peptide levels in the paraventricular nucleus of the hypothalamus (PVN)

• no change in the level of vasopression (AVP)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary hyperaldosteronism		DOID:446	OMIM:605635 OMIM:613677	J:57315

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:150544 )

• spontaneous firing rate of dopamine neurons is highly reduced in ventral tegmental area (VTA)

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Wap-cre)1Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Wap-cre)1Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:95548 )

• between day 14.5 of pregnancy (P14.5) and P18.5, lobuloalveolar development was retarded, however milk protein expression is normal and females are able to nurse pups although pups weight 20% less during the first 10 days after birth

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy

abnormal mammary gland alveolus morphology ( J:95548 )

• although secretory alveoli form, less space is occupied by epithelial structures and more space is occupied by fat compared to controls during pregnancy and throughout lactation indicating that alveolar lobes do not completely penetrate the mammary fat pad

reproductive system

abnormal mammary gland growth during pregnancy ( J:95548 )

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy

integument

abnormal mammary gland growth during pregnancy ( J:95548 )

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy

abnormal mammary gland alveolus morphology ( J:95548 )

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating corticosterone level ( J:125230 )

• when treated with tamoxifen the level of serum corticosterone is increased to 39+/-8 ng/ml when one copies of the transgene is present, 100+/-20 ng/ml when two copies of the transgene are present and 108+/-19 ng/ml when four copies of the transgene are present compared to 13+/-5 ng/ml in wild-type

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Runx2-icre)1Jtuc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Runx2-icre)1Jtuc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body length ( J:160669 )

• males exhibit a slight increase in crown-rump length compared to controls at 10 weeks

skeleton

skeleton phenotype ( J:160669 )

N	• bone resorption is slightly decreased in both mutants and controls while osteoclast numbers are not affected

abnormal osteoblast differentiation ( J:160669 )

• calvarial osteoblasts exhibit diminished differentiation potential in terms of bone nodule formation and alkaline phosphatase expression

• with prednisolone treatment, osteoblast differentiation is impaired in wild-type mice, but is unaffected in mutants, as determined by Col1a1 expression, marking functional osteoblasts

abnormal bone mineral density ( J:160669 )

• in response to two weeks of treatment with the Nr3c1 agonist prednisolone, mutants do not display reduced bone mineral density in vertebral bones in contrast to treated controls

decreased bone mineral density ( J:160669 )

• mice show modest but highly significant decrease in bone density in calcified vertebral sections compared to controls at 3 months

decreased bone trabecula number ( J:160669 )

increased bone trabecular spacing ( J:160669 )

• trabecular numbers are decreased but trabecular thickness is unaltered resulting in increased trabecular spacing

• osteoblast numbers, osteoblast surface, osteocytes, and osteoclast parameters are not significantly changed compared to controls

abnormal bone ossification ( J:160669 )

• bone formation in vertebrae is not inhibited whereas treated controls show near complete inhibition of bone formation with prednisolone treatment; osteoblastogenesis (numbers of colony forming units of osteoblasts) is not impaired as seen in controls with prednisolone treatment

cellular

abnormal osteoblast differentiation ( J:160669 )

• calvarial osteoblasts exhibit diminished differentiation potential in terms of bone nodule formation and alkaline phosphatase expression

• with prednisolone treatment, osteoblast differentiation is impaired in wild-type mice, but is unaffected in mutants, as determined by Col1a1 expression, marking functional osteoblasts

Allelic Composition	Nr3c1^tm2Gsc/Nr3c1^tm2Gsc Tg(Alb1-cre)7Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Alb1-cre)7Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:121556 )

• reduced body weight starting around 3 weeks of age

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