Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm3Gsc mutation
(1 available);
any
Nr3c1 mutation
(35 available)
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hematopoietic system
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• E14.5 fetal liver cultures fail to exhibit outgrowths of erythroid progenitor cells as do wild-type livers
• mice treated with phenylhydrazine to induce anemia or exposed to hypoxic conditions fail to exhibit an increase in colony forming unit-erythroid cells unlike in similarly treated wild-type mice
• fetal liver cells transplanted into irradiated wild-type mice fail to respond normally with increased erythroid progenitor cell numbers to hypoxic conditions
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm3Gsc mutation
(1 available);
any
Nr3c1 mutation
(35 available)
|
|
|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm3Gsc mutation
(1 available);
any
Nr3c1 mutation
(35 available)
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skeleton
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N |
• bone formation with prednisolone treatment for 2 weeks is repressed in controls and mutants; bone mass and trabecular thickness as well as strong reduction in osteoblast and osteocyte numbers and osteoblast surface area are observed in controls and experimental animals with inhibition of bone formation by prednisolone
• dexamethasone-induced apoptosis is observed in cultured mutant and wild-type cells
• in dexamethasone-treated cultures, postconfluential cell numbers are slightly decreased, similar to wild-type cultures
• alkaline phosphatase activity and matrix mineralization are inhibited by dexamethasone treatment in mutant and wild-type cultures
• basal osteoclastogenesis is not affected in mutant cell culture; dexamethasone suppresses osteoclastogenesis similary in mutant and wild-type cultures
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• proliferation of preconfluent preosteoblasts from neonatal calvaria is lower in culture compared to wild-type cells
• treatment with dexamethasone does not affect mutant cells but completely inhibits osteoblast proliferation in cultures of wild-type cells
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cellular
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• proliferation of preconfluent preosteoblasts from neonatal calvaria is lower in culture compared to wild-type cells
• treatment with dexamethasone does not affect mutant cells but completely inhibits osteoblast proliferation in cultures of wild-type cells
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Analysis Tools