Phenotypes associated with this allele

• Allele Symbol: Nr5a1^tm1Jmi
• Allele Name: targeted mutation 1, Jeffrey Milbrandt
• Allele ID: MGI:1931426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr5a1^tm1Jmi/Nr5a1^tm1Jmi	involves: 129X1/SvJ	MGI:2180051

Genotype
MGI:2180051

hm1

• Allelic Composition: Nr5a1^tm1Jmi/Nr5a1^tm1Jmi
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:35577 )

• animals die within 48 hours of birth

endocrine/exocrine glands

absent adrenal gland ( J:35577 )

agonadal ( J:35577 )

• absence of testis and ovaries in males and females, respectively

absent ovary ( J:35577 )

• females lacked ovaries

absent testes ( J:35577 )

• males lacked testes

reproductive system

abnormal primary sex determination ( J:35577 )

agonadal ( J:35577 )

• absence of testis and ovaries in males and females, respectively

absent ovary ( J:35577 )

• females lacked ovaries

absent testes ( J:35577 )

• males lacked testes

secondary sex reversal ( J:35577 )

• genotypic males also develop uterine horns and oviducts due to lack Amh