About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-K1b-tm1Bpe
targeted mutation 1, Beatrice Perarnau
MGI:1931444
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2-K1b-tm1Bpe/H2-K1b-tm1Bpe involves: 129P2/OlaHsd * C57BL/6 MGI:3623452
cx2
 		H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe 		B6.129P-H2-D1b-tm1Bpe H2-K1b-tm1Bpe MGI:3701875
cx3
 		H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
X/Yaa 		BXSB.129P2(B6)-H2-K1b-tm1Bpe H2-D1b-tm1Bpe/Dcr MGI:6094247
cx4
 		H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok 		involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac MGI:6196216
cx5
 		H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok
Tg(H2-Dd)28Bee/0 		involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac * DBA/2 MGI:6196218
cx6
 		H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe 		involves: 129P2/OlaHsd * C57BL/6 MGI:3623453


Genotype
MGI:3623452
hm1
Allelic
Composition		 H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD4-positive, alpha-beta T cell number ( J:54709 )
• numbers increase in parallel to decrease in CD8+ cells
decreased CD8-positive, alpha-beta T cell number ( J:54709 )
• 30-50% reduction of single positive CD8 peripheral T-cells

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:54709 )
• numbers increase in parallel to decrease in CD8+ cells
decreased CD8-positive, alpha-beta T cell number ( J:54709 )
• 30-50% reduction of single positive CD8 peripheral T-cells




Genotype
MGI:3701875
cx2
Allelic
Composition		 H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Genetic
Background		 B6.129P-H2-D1b-tm1Bpe H2-K1b-tm1Bpe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytotoxic T cell physiology ( J:118960 )
• in infected mutants, an enhanced H2-M3/LemA-specific response compared to wild-type is detected after injection of B6 splenocytes pulsed with this peptide
• number of H2-M3/LemA-specific CD8+ T cells is drastically increased compared to wild-type during primary LM infection

hematopoietic system
abnormal cytotoxic T cell physiology ( J:118960 )
• in infected mutants, an enhanced H2-M3/LemA-specific response compared to wild-type is detected after injection of B6 splenocytes pulsed with this peptide
• number of H2-M3/LemA-specific CD8+ T cells is drastically increased compared to wild-type during primary LM infection




Genotype
MGI:6094247
cx3
Allelic
Composition		 H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
X/Yaa
Genetic
Background		 BXSB.129P2(B6)-H2-K1b-tm1Bpe H2-D1b-tm1Bpe/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to systemic lupus erythematosus ( J:179430 )
• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of MHC class I molecules intensifies the severity to a mean survival of only 25 weeks of age

mortality/aging




Genotype
MGI:6196216
cx4
Allelic
Composition		 H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
Klra1tm1.1Wyok mutation (0 available); any Klra1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:252851 )
N
• total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1




Genotype
MGI:6196218
cx5
Allelic
Composition		 H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok
Tg(H2-Dd)28Bee/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
Klra1tm1.1Wyok mutation (0 available); any Klra1 mutation (17 available)
Tg(H2-Dd)28Bee mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:252851 )
N
• total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression
abnormal NK cell physiology ( J:252851 )
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele (MGI:6196216)
• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele (MGI:6196216)

immune system
abnormal NK cell physiology ( J:252851 )
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele (MGI:6196216)
• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele (MGI:6196216)




Genotype
MGI:3623453
cx6
Allelic
Composition		 H2-D1b-tm1Bpe/H2-D1b-tm1Bpe
H2-K1b-tm1Bpe/H2-K1b-tm1Bpe
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation (10 available); any H2-D1 mutation (47 available)
H2-K1b-tm1Bpe mutation (10 available); any H2-K1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:54709 )
• survive infection with Lymphocytic Choriomeningitis Virus

immune system
increased CD4-positive, alpha-beta T cell number ( J:54709 )
• numbers increase in parallel to decrease in CD8+ cells
decreased CD8-positive, alpha-beta T cell number ( J:54709 )
• 90% reduction of single positive CD8 peripheral T-cells
absent CD8-positive, alpha-beta T cells ( J:57703 )
• CD8+ TCRalpha/beta T-cells not present
decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:54709 )
• survive infection with Lymphocytic Choriomeningitis Virus

nervous system
nervous system phenotype ( J:148342 )
N
• normal gross cerebellar development
abnormal glutamate-mediated receptor currents ( J:148342 )
• increased glutamate transients in climbing fiber synaptic clefts
increased synaptic depression ( J:148342 )
• lower threshold for induction if climbing fibers are involved in induction
enhanced paired-pulse facilitation ( J:148342 )
• larger paired pulse ratio when paired stimuli are applied to climbing fibers are separated by 50-100 msec
• significantly increased second excitatory postsynaptic current

behavior/neurological
enhanced coordination ( J:148342 )
• performance in rotarod tests is significantly better than controls on the third day of testing
• testing repeated after 2 weeks of rest and then after another 4 months of rest indicate much better task retention than for controls

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:54709 )
• numbers increase in parallel to decrease in CD8+ cells
decreased CD8-positive, alpha-beta T cell number ( J:54709 )
• 90% reduction of single positive CD8 peripheral T-cells
absent CD8-positive, alpha-beta T cells ( J:57703 )
• CD8+ TCRalpha/beta T-cells not present




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory