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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Proztm1Gjb
targeted mutation 1, George J Broze, Jr
MGI:1931524
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Proztm1Gjb/Proztm1Gjb involves: 129X1/SvJ MGI:3804659
hm2
 		Proztm1Gjb/Proztm1Gjb involves: 129X1/SvJ * C57BL/6 MGI:3789951
cx3
 		F5tm2Dgi/F5+
Proztm1Gjb/Proztm1Gjb 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3789948
cx4
 		F5tm2Dgi/F5tm2Dgi
Proztm1Gjb/Proztm1Gjb 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3789949
cx5
 		F5tm2Dgi/F5tm2Dgi
Proztm1Gjb/Proz+ 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3789950


Genotype
MGI:3804659
hm1
Allelic
Composition		 Proztm1Gjb/Proztm1Gjb
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Proztm1Gjb mutation (0 available); any Proz mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:136102 )
• mice show increased mortality in a collagen/epinephrine-induced thromboembolism model, with 71% of mice dying of respiratory arrest within 5 minutes of model induction compared to 27% in wild-type mice

homeostasis/metabolism
increased susceptibility to induced thrombosis ( J:136102 )
• ferric chloride-induced carotid artery injury leads to 64% occlusion after 40 minutes, which is significantly higher than the 28% occlusion that occurs in wild-type mice
• there is also increased mortality in a thromboembolism model




Genotype
MGI:3789951
hm2
Allelic
Composition		 Proztm1Gjb/Proztm1Gjb
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Proztm1Gjb mutation (0 available); any Proz mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:62716 )
• mice show normal growth and development, and hematopoietic parameters are grossly normal




Genotype
MGI:3789948
cx3
Allelic
Composition		 F5tm2Dgi/F5+
Proztm1Gjb/Proztm1Gjb
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5tm2Dgi mutation (1 available); any F5 mutation (159 available)
Proztm1Gjb mutation (0 available); any Proz mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:62716 )
• fewer (only 10% of expected 50%) animals of this genotype are found at 6 weeks




Genotype
MGI:3789949
cx4
Allelic
Composition		 F5tm2Dgi/F5tm2Dgi
Proztm1Gjb/Proztm1Gjb
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5tm2Dgi mutation (1 available); any F5 mutation (159 available)
Proztm1Gjb mutation (0 available); any Proz mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:62716 )
• mortality of double homozygotes is high; only 1 animal reached adulthood (6 weeks)

cardiovascular system
hemorrhage ( J:62716 )
• at E17.5-18.5, almost all mutants show signs of hemorrhage

homeostasis/metabolism
abnormal thrombosis ( J:62716 )
• at E17.5-18.5, embryos display thrombosis and fibrin depositon in the vasculature




Genotype
MGI:3789950
cx5
Allelic
Composition		 F5tm2Dgi/F5tm2Dgi
Proztm1Gjb/Proz+
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5tm2Dgi mutation (1 available); any F5 mutation (159 available)
Proztm1Gjb mutation (0 available); any Proz mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:62716 )
• fewer (37% of expected 50%) animals of this genotype are found at 6 weeks

homeostasis/metabolism
abnormal thrombosis ( J:62716 )
• less severe than in double homozygous embryos




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory