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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Serpinb2tm1Dgi
targeted mutation 1, David Ginsburg
MGI:1931532
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Serpinb2tm1Dgi/Serpinb2tm1Dgi involves: 129S2/SvPas * C57BL/6J * DBA/2J MGI:3037850
cx2
 		Serpinb2tm1Dgi/Serpinb2tm1Dgi
Serpine1tm1Mlg/Serpine1tm1Mlg 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * DBA/2 MGI:4837628
cx3
 		Dusp5tm1.1Skey/Dusp5tm1.1Skey
Serpinb2tm1Dgi/Serpinb2tm1Dgi 		involves: 129S1/Sv * C57BL/6 * C57BL/6NTac MGI:5906772


Genotype
MGI:3037850
hm1
Allelic
Composition		 Serpinb2tm1Dgi/Serpinb2tm1Dgi
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb2tm1Dgi mutation (1 available); any Serpinb2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:52283 )
• decreased platelet count of marginal significance
abnormal leukocyte cell number ( J:52283 )
• a marginally significant decrease in leukocyte count involving lymphocytes, neutrophils, and monocytes

immune system
immune system phenotype ( J:52283 )
N
• mice exhibit normal response to bacterial infectious challenge or endotoxin infusion
abnormal leukocyte cell number ( J:52283 )
• a marginally significant decrease in leukocyte count involving lymphocytes, neutrophils, and monocytes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:52283 )
N
• mice exhibit normal wound healing




Genotype
MGI:4837628
cx2
Allelic
Composition		 Serpinb2tm1Dgi/Serpinb2tm1Dgi
Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpinb2tm1Dgi mutation (1 available); any Serpinb2 mutation (32 available)
Serpine1tm1Mlg mutation (3 available); any Serpine1 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:52283 )
N
• mice exhibit normal wound healing




Genotype
MGI:5906772
cx3
Allelic
Composition		 Dusp5tm1.1Skey/Dusp5tm1.1Skey
Serpinb2tm1Dgi/Serpinb2tm1Dgi
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp5tm1.1Skey mutation (0 available); any Dusp5 mutation (16 available)
Serpinb2tm1Dgi mutation (1 available); any Serpinb2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:216939 )
N
• mice exhibit normal susceptibility to DMBA/TPA-induced skin papilloma




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory