All Phenotypes Itgam<tm1Myd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgam^tm1Myd/Itgam^tm1Myd	B6.129S4-Itgam^tm1Myd	MGI:3785288
hm2	Itgam^tm1Myd/Itgam^tm1Myd	involves: 129S4/SvJae	MGI:4415252
hm3	Itgam^tm1Myd/Itgam^tm1Myd	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:3620576
hm4	Itgam^tm1Myd/Itgam^tm1Myd	involves: 129S4/SvJae * C57BL/6	MGI:3620585
cn5	Itgam^tm1Myd/Itgam^tm1Myd Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:4415250

Allelic Composition	Itgam^tm1Myd/Itgam^tm1Myd
Genetic Background	B6.129S4-Itgam^tm1Myd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgam^tm1Myd mutation (1 available); any Itgam mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal neutrophil morphology ( J:113463 )

• neutrophils that accumulate at the site of a local Shwartman response are round instead of flattened as in wild-type mice

abnormal neutrophil physiology ( J:113463 )

• neutrophil degranulation after adhesion is decreased compared to in wild-type mice

abnormal inflammatory response ( J:113463 )

• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice fail to exhibit hemorrhage and have fewer thrombus-occluded vessels and reduced fibrin compared to the thrombohemorrhagic vasculitis observed in wild-type mice

• however, neutrophil accumulation at the site of the Shwartman response is normal and adoptive transfer of neutrophils into a wild-type mouse elicits a normal local Shwartman response

homeostasis/metabolism

abnormal blood homeostasis ( J:113463 )

• mouse serum fails to support neutrophil adhesion unlike serum from wild-type mice

hematopoietic system

abnormal neutrophil morphology ( J:113463 )

• neutrophils that accumulate at the site of a local Shwartman response are round instead of flattened as in wild-type mice

abnormal neutrophil physiology ( J:113463 )

• neutrophil degranulation after adhesion is decreased compared to in wild-type mice

Allelic Composition	Itgam^tm1Myd/Itgam^tm1Myd
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgam^tm1Myd mutation (1 available); any Itgam mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired leukocyte tethering or rolling ( J:198197 )

• absence of rolling following needle puncture of mesenteric veins

impaired neutrophil phagocytosis ( J:155479 )

cellular

impaired leukocyte tethering or rolling ( J:198197 )

• absence of rolling following needle puncture of mesenteric veins

impaired neutrophil phagocytosis ( J:155479 )

hematopoietic system

impaired leukocyte tethering or rolling ( J:198197 )

• absence of rolling following needle puncture of mesenteric veins

impaired neutrophil phagocytosis ( J:155479 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:38052 )

• in cultured total leukocyte populations from harvested peritoneal exudates, extravasated null neutrophils show a 56% and 45% reduction in apoptosis after 6 and 8 hours in culture respectively, compared to wild-type neutrophils

abnormal leukocyte adhesion ( J:38052 )

• neutrophils from null animals are significantly impaired with respect to their ability to adhere to the endothelium in response to leukotriene B4

impaired neutrophil phagocytosis ( J:38052 )

• null neurophils isolated from peritoneal lavage of thioglycollate-treated mice are unable to phagocytose complement-opsonized particles; neutrophil spreading on glass is attenuated in null neutrophils; these neutrophils also show a 60% reduction in the oxidative burst associated with phagocytosis

hematopoietic system

abnormal leukocyte adhesion ( J:38052 )

• neutrophils from null animals are significantly impaired with respect to their ability to adhere to the endothelium in response to leukotriene B4

impaired neutrophil phagocytosis ( J:38052 )

increased eosinophil cell number ( J:38052 )

• mutants show increased eosinophil accumulation at 10.5 hours, 48 hours and 5 days in the model of peritonitis

increased neutrophil cell number ( J:38052 )

• null animals have 2-fold more neutrophils in the peritoneal exudates after 2 hours in an experimental model of peritonitis than did wild-type animals

immune system

abnormal leukocyte adhesion ( J:38052 )

• neutrophils from null animals are significantly impaired with respect to their ability to adhere to the endothelium in response to leukotriene B4

impaired neutrophil phagocytosis ( J:38052 )

increased eosinophil cell number ( J:38052 )

• mutants show increased eosinophil accumulation at 10.5 hours, 48 hours and 5 days in the model of peritonitis

increased neutrophil cell number ( J:38052 )

• null animals have 2-fold more neutrophils in the peritoneal exudates after 2 hours in an experimental model of peritonitis than did wild-type animals

Allelic Composition	Itgam^tm1Myd/Itgam^tm1Myd
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgam^tm1Myd mutation (1 available); any Itgam mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased cerebral infarct size ( J:103873 )

• after 3 hours of focal ischemia and 21 hours of reperfusion, infarct volume in wild-type mice is 79.4 cubic mm versus 58.9 cubic mm in homozygous animals (26% reduction in tissue injury)

hematopoietic system

decreased neutrophil cell number ( J:103873 )

• reduction in infarct size is accompanied by a 50% reduction in neutrophils in the periphery of the infarct area, although this is not statistically significant

immune system

decreased neutrophil cell number ( J:103873 )

• reduction in infarct size is accompanied by a 50% reduction in neutrophils in the periphery of the infarct area, although this is not statistically significant

homeostasis/metabolism

decreased cerebral infarct size ( J:103873 )

• after 3 hours of focal ischemia and 21 hours of reperfusion, infarct volume in wild-type mice is 79.4 cubic mm versus 58.9 cubic mm in homozygous animals (26% reduction in tissue injury)

Allelic Composition	Itgam^tm1Myd/Itgam^tm1Myd Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgam^tm1Myd mutation (1 available); any Itgam mutation (48 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice

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