Phenotypes associated with this allele

• Allele Symbol: Acvr1^tm1Bhr
• Allele Name: targeted mutation 1, Richard R Behringer
• Allele ID: MGI:1931734
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acvr1^tm1Bhr/Acvr1^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6	MGI:2183232
hm2	Acvr1^tm1Bhr/Acvr1^tm1Bhr	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3697610

Genotype
MGI:2183232

hm1

• Allelic Composition: Acvr1^tm1Bhr/Acvr1^tm1Bhr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:57670 )

• embryos are abnormal or degenerating between E7 and E8.5

embryo

abnormal mesoderm development ( J:57670 )

• mesodermal wings form, but do not extend posteriorly

• mesoderm formation is initiated as indicated by marker analysis but is is not fully differentiated

embryonic growth arrest ( J:57670 )

• development is arrested at mid/late streak stage

decreased embryo size ( J:57670 )

• at E7, embryos are about half the size of controls

abnormal embryonic epiblast morphology ( J:57670 )

• the posterior epiblast is forced into the proamniotic cavity by the thickened primitive streak

abnormal primitive streak formation ( J:57670 )

• forms but is thickened

• the thickened primitive streak forces the posterior epiblast into the proamniotic cavity

disorganized embryonic tissue ( J:57670 )

• no organized structures are observed in the E7 embryos

absent allantois ( J:57670 )

growth/size/body

decreased embryo size ( J:57670 )

• at E7, embryos are about half the size of controls

Genotype
MGI:3697610

hm2

• Allelic Composition: Acvr1^tm1Bhr/Acvr1^tm1Bhr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

growth/size/body

decreased embryo size ( J:117234 )

• starting at E7-E7.5, embryos are much smaller

embryo

abnormal gastrulation ( J:117234 )

• at E7-7.5, embryos form empty sacs composed of parietal endoderm as the epiblast is forced into the proamniotic cavity

abnormal mesoderm development ( J:117234 )

• mesoderm formation is initiated but the subsequent development is arrested during the mid-late streak stages

embryonic growth arrest ( J:117234 )

• at the mid-late streak stage

decreased embryo size ( J:117234 )

• starting at E7-E7.5, embryos are much smaller

abnormal embryonic epiblast morphology ( J:117234 )

• the posterior epiblast is forced into the proamniotic cavity by the thicker primitive streak

abnormal primitive streak morphology ( J:117234 )

• thicker primitive streak that forces the posterior epiblast into to the proamniotic cavity