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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Jag1Slalom
slalom
MGI:1931798
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Jag1Slalom/Jag1Slalom involves: BALB/c * C3H MGI:3587505
ht2
Jag1Slalom/Jag1+ involves: BALB/c * C3H MGI:3587506
ht3
Jag1Mhdahtu/Jag1Slalom involves: BALB/c * C3H * C3HeB/FeJ MGI:3717465


Genotype
MGI:3587505
hm1
Allelic
Composition
Jag1Slalom/Jag1Slalom
Genetic
Background
involves: BALB/c * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Slalom mutation (2 available); any Jag1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• reduced large vasculature in yolk sac
• neural tube defects in about 30% of embryos

nervous system
• neural tube defects in about 30% of embryos

cardiovascular system
• reduced large vasculature in yolk sac




Genotype
MGI:3587506
ht2
Allelic
Composition
Jag1Slalom/Jag1+
Genetic
Background
involves: BALB/c * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Slalom mutation (2 available); any Jag1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• subtle headweaving/shaking behavior
• described as poor negative geotaxis

hearing/vestibular/ear
• supernumary or atypical outer hair cells sometimes found in inner hair cell rows
• reduced numbers of outer hair cells
• some regions lacking entire rows while isolated hair cells missing in other regions
• decreased outer hair cell counts in both basal and apical turns
• significantly increased inner hair cell counts in base of cochlea but not apical regions
• either posterior or anterior semicircular canal truncated
• sometimes both anterior and posterior semicircular canals absent

nervous system
• reduced numbers of outer hair cells
• some regions lacking entire rows while isolated hair cells missing in other regions
• decreased outer hair cell counts in both basal and apical turns
• significantly increased inner hair cell counts in base of cochlea but not apical regions




Genotype
MGI:3717465
ht3
Allelic
Composition
Jag1Mhdahtu/Jag1Slalom
Genetic
Background
involves: BALB/c * C3H * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1Mhdahtu mutation (2 available); any Jag1 mutation (78 available)
Jag1Slalom mutation (2 available); any Jag1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• absence of blood vessels in the yolk sac
• embryos are either necrotic or hemorrhagic

cardiovascular system
• absence of blood vessels in the yolk sac
• embryos are either necrotic or hemorrhagic





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory