All Phenotypes Il13<tm2Anjm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il13^tm2Anjm
targeted mutation 2, Andrew NJ McKenzie
MGI:1931804

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il13^tm2Anjm/Il13^tm2Anjm	B6.129P2-Il13^tm2Anjm	MGI:5432708
hm2	Il13^tm2Anjm/Il13^tm2Anjm	C.129P2(B6)-Il13^tm2Anjm	MGI:3038308
hm3	Il13^tm2Anjm/Il13^tm2Anjm	involves: 129	MGI:3850549
hm4	Il13^tm2Anjm/Il13^tm2Anjm	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:5432601
hm5	Il13^tm2Anjm/Il13^tm2Anjm	involves: 129P2/OlaHsd * C57BL/6	MGI:3038307
cx6	Il13^tm2Anjm/Il13^tm2Anjm Tg(SFTPC-Il18)AThos/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2	MGI:5688502

Allelic Composition	Il13^tm2Anjm/Il13^tm2Anjm
Genetic Background	B6.129P2-Il13^tm2Anjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm2Anjm mutation (6 available); any Il13 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased macrophage cell number ( J:131969 )

• decrease in the number of CD11b+ cells in the brain and spinal cord in female mice

abnormal leukocyte physiology ( J:131969 )

• production of IL12 and IFNG by mononuclear cells from female mice stimulated with MOG-35?55 is significantly reduced compared to cells from male mice

• production of EAE associated chemokines by mononuclear cells from female mice is reduced compared to cells from male mice

abnormal antigen presentation ( J:131969 )

• antigen presenting cells taken from female mice at the peak of EAE stimulated with MOG-35?55 present antigen with reduced efficiency compared to cells from male mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:131969 )

• females develop EAE with reduced severity or are resistant to EAE compared to wild-type females

• however, EAE severity in males is similar to wild-type males

hematopoietic system

decreased macrophage cell number ( J:131969 )

• decrease in the number of CD11b+ cells in the brain and spinal cord in female mice

abnormal leukocyte physiology ( J:131969 )

• production of IL12 and IFNG by mononuclear cells from female mice stimulated with MOG-35?55 is significantly reduced compared to cells from male mice

• production of EAE associated chemokines by mononuclear cells from female mice is reduced compared to cells from male mice

Allelic Composition	Il13^tm2Anjm/Il13^tm2Anjm
Genetic Background	C.129P2(B6)-Il13^tm2Anjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm2Anjm mutation (6 available); any Il13 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal type I hypersensitivity reaction ( J:123772 )

• neutralizing IL14 reduces response in sensitized mice down to that in unsensitized mice, unlike in wild-type mice

• neutralizing IL15 also reduces response in sensitized mutant mice but not in wild-type mice

increased susceptibility to type I hypersensitivity reaction ( J:123772 )

• show a heightened response relative to wild-type mice in a model of airways hyperreactivity (sensitized and aeroallergen challenged with OVA followed by challenge with Beta-metacholine)

• however, mucus hypersecretion in this model of airways hyperreactivity is reduced

abnormal response to transplant ( J:110188 )

• decrease in luminal occlusion in tracheal allografts from C57BL/6 mice compared to transplants into wild-type mice

• allografts do not show a significant upregulation of TGFB1 compared to isografts

increased length of allograft survival ( J:110188 )

• tracheal allografts from C57BL/6 mice display prolonged maintenance of epithelial integrity and absence of luminal fibroproliferation

homeostasis/metabolism

decreased susceptibility to injury ( J:88681 )

• decreased pulmonary fibrosis is seen after FITC treatment most likely a result of an overall decrease in collagen production

Allelic Composition	Il13^tm2Anjm/Il13^tm2Anjm
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm2Anjm mutation (6 available); any Il13 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T-helper 2 cell differentiation ( J:67965 )

• much fewer Th2 cells are developed in vitro when nave CD4 T cells are cultured under Th2-polarizing conditions

• Th2 cells are produced under chronic N. brasiliensis infection

decreased T-helper 2 cell number ( J:67965 )

• much fewer Th2 cells are found in vitro

decreased IgE level ( J:67965 )

• total IgE levels are decreased 5- to 20- fold

• however, IgE levels are comparable to wild-type when mice are immunized

increased IgG2b level ( J:67965 )

• there are increased amounts of antigen-specific IgG2b levels when mice are immunized compared to controls

increased IgM level ( J:67965 )

• there are increased amounts of antigen-specific IgM levels when mice are immunized compared to control

homeostasis/metabolism

decreased circulating interleukin-13 level ( J:67965 )

• IL-13 are absent in these mice

immune system

abnormal T-helper 2 cell differentiation ( J:67965 )

• much fewer Th2 cells are developed in vitro when nave CD4 T cells are cultured under Th2-polarizing conditions

• Th2 cells are produced under chronic N. brasiliensis infection

decreased T-helper 2 cell number ( J:67965 )

• much fewer Th2 cells are found in vitro

decreased IgE level ( J:67965 )

• total IgE levels are decreased 5- to 20- fold

• however, IgE levels are comparable to wild-type when mice are immunized

increased IgG2b level ( J:67965 )

• there are increased amounts of antigen-specific IgG2b levels when mice are immunized compared to controls

increased IgM level ( J:67965 )

• there are increased amounts of antigen-specific IgM levels when mice are immunized compared to control

decreased circulating interleukin-13 level ( J:67965 )

• IL-13 are absent in these mice

increased interferon-gamma secretion ( J:67965 )

• IFN-gamma secretion is 2-fold compared to controls when CD4 T cells are restimulated compared to controls

decreased interleukin-10 secretion ( J:67965 )

• IL-10 secretion is reduced 2-fold compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions

decreased interleukin-4 secretion ( J:67965 )

• IL-4 secretion is dramatically decreased compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions

• schistosome eggs, an antigen that induces Th2 cell responses, induces a 2-fold decreased IL-4 response than controls

decreased interleukin-5 secretion ( J:67965 )

• IL-5 secretion is dramatically decreased compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions

• schistosome eggs, an antigen that induces Th2 cell responses, induces a 2-fold decreased IL-5 response than controls

Allelic Composition	Il13^tm2Anjm/Il13^tm2Anjm
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm2Anjm mutation (6 available); any Il13 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• decreased mortality following acute infection with Schistosoma mansoni compared to wild-type mic

immune system

impaired eosinophil recruitment ( J:126675 )

• in mice sensitized by injection of alum-precipitated chicken egg ovalbumin the exposed to low levels of aerosolized antigen little evidence of recruitment of eosinophils into the tracheal epithelium is seen

impaired neutrophil recruitment ( J:105813 )

• to the liver following ischemia/reperfusion resulting from an apparent defect in transendothelial migration

abnormal macrophage physiology ( J:176092 )

• phagocytosis of Chlamydia muridarum is enhanced in vitro and in vivo

abnormal chemokine level ( J:131994 )

• in mice immunized with recombinant vvG levels of CCL11 and CCL22 are reduced in the lungs

abnormal susceptibility to infection ( J:131994 )

• mice immunized with recombinant vvG (vaccinia virus expressing the G protein of respiratory syncytial virus (RSV)) then challenged with RSV display lower percentages and total numbers of eosinophils in the bronchoalveolar lavage (BAL) compared to wild-type mice

• in mice immunized with recombinant vvG and then challenged with RSV eosinophilia in both perivascular and interstitial regions of the lung is significantly decreased

• however, levels of eosinophils in the blood and bone marrow are similar to controls

decreased susceptibility to bacterial infection ( J:176092 )

• after respiratory infection with Chlamydia muridarum (Cmu) mice do not lose weight, show reduced bacterial loads in the lungs and reduced airway inflammation

• mice are also resistant to genital tract Cmu infection

decreased susceptibility to parasitic infection ( J:60609 )

• negligible hepatic fibrosis following infection with Schistosoma mansoni unlike in wild-type mice

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• decreased mortality following acute infection with Schistosoma mansoni compared to wild-type mic

homeostasis/metabolism

abnormal chemokine level ( J:131994 )

• in mice immunized with recombinant vvG levels of CCL11 and CCL22 are reduced in the lungs

abnormal response to injury ( J:105813 )

• increased liver damage following liver ischemia/reperfusion indicated by increased serum ALT levels and marked destruction of hepatocellular structure throughout the liver

• increased susceptibility to hepatic vascular endothelial cell injury during early periods of reperfusion

hematopoietic system

impaired eosinophil recruitment ( J:126675 )

impaired neutrophil recruitment ( J:105813 )

• to the liver following ischemia/reperfusion resulting from an apparent defect in transendothelial migration

abnormal macrophage physiology ( J:176092 )

• phagocytosis of Chlamydia muridarum is enhanced in vitro and in vivo

Allelic Composition	Il13^tm2Anjm/Il13^tm2Anjm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm2Anjm mutation (6 available); any Il13 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• decreased mortality following chronic infection with Schistosoma mansoni compared to wild-type mice

immune system

immune system phenotype ( J:72587 )

N	• development of skin lesion sin response to Leishmania mexicana infection is similar to that in wild-type mice

abnormal T-helper 2 physiology ( J:89095 )

• homozygotes display impaired pulmonary granuloma formation in response to schistosome egg immunization

• eosinophil infiltration is impaired in response to schistosome egg immunization

abnormal splenocyte physiology ( J:72587 )

• Leishmania mexicana antigen stimulated cells from L. mexicana infected mice produce increased amounts of IL12

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• decreased mortality following chronic infection with Schistosoma mansoni compared to wild-type mice

increased susceptibility to parasitic infection ( J:89095 )

• the expulsion of parasitic worms from the gut is delayed

hematopoietic system

abnormal T-helper 2 physiology ( J:89095 )

• homozygotes display impaired pulmonary granuloma formation in response to schistosome egg immunization

• eosinophil infiltration is impaired in response to schistosome egg immunization

abnormal splenocyte physiology ( J:72587 )

• Leishmania mexicana antigen stimulated cells from L. mexicana infected mice produce increased amounts of IL12

Allelic Composition	Il13^tm2Anjm/Il13^tm2Anjm Tg(SFTPC-Il18)AThos/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm2Anjm mutation (6 available); any Il13 mutation (30 available)
Tg(SFTPC-Il18)AThos mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:219136 )

• mice show a decrease in body weight from 16 to 24 weeks of age, however weight loss is less than seen in single transgenic Tg(SFTPC-Il18)AThos mice

respiratory system

abnormal pulmonary alveolus morphology ( J:147547 )

• mean alveolar chord lengths of 14 week old mice is shorter than in single transgenic mice

• however, pulmonary inflammation and emphysematous changes are not seen in the lungs enlarged alveolar macrophages and exudates are not present in the lungs

muscle

decreased skeletal muscle weight ( J:219136 )

• decrease in quadriceps femoris muscle weight at 7 and 16 weeks of age, although muscle is heavier than in single transgenic Tg(SFTPC-Il18)AThos mice and by 25 weeks of age, weight is similar to wild-type mice

• mice show a decrease in gastrocnemius muscle weight at 7 weeks of age but not 16 and 25 weeks of age

skeleton

skeleton phenotype ( J:219136 )

N	• bone mineral density is normal

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