All Phenotypes Il13<tm1.1Anjm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il13^tm1.1Anjm/Il13^tm1.1Anjm	C.129P2-Il13^tm1.1Anjm	MGI:3850554
hm2	Il13^tm1.1Anjm/Il13^tm1.1Anjm	involves: 129P2/OlaHsd * C57BL/6	MGI:3850548
cx3	Il13^tm1.1Anjm/Il13^tm1.1Anjm Tg(DO11.10)10Dlo/0	involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6	MGI:3850558

Allelic Composition	Il13^tm1.1Anjm/Il13^tm1.1Anjm
Genetic Background	C.129P2-Il13^tm1.1Anjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm1.1Anjm mutation (0 available); any Il13 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell differentiation ( J:141937 )

• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced although not to the degree found in IL-4 null mice

decreased IgE level ( J:91403 )

• less antigen-specific IgE is made compared to controls during an induced airway hyperresponsiveness model

increased IgG2a level ( J:91403 )

• more antigen-specific IgG2a is made compared to controls during an induced airway hyperresponsiveness model

abnormal dendritic cell antigen presentation ( J:141937 )

• DCs from inflamed lungs encourage expression of IFN-gamma in the memory T cells they activate compared to controls

increased interferon-gamma secretion ( J:141937 )

• T cells from mice sensitized and challenged with OVA produce more IFN-gamma than controls

decreased interleukin-13 secretion ( J:91403 , J:141937 )

• lymphocytes fail to produce IL-13 (J:91403)

• lymphocytes fail to produce IL-13 (J:141937)

decreased interleukin-5 secretion ( J:141937 )

• lymphocytes from mice sensitized and challenged with OVA produce less IL-5 than controls

decreased susceptibility to autoimmune disorder ( J:91403 , J:141937 )

• mice fail to develop airway hyperresponsiveness (AHR) after first being sensitized and challenged with OVA peptide (J:91403)

• in these mice, inflammation with eosinophil infiltrates occurs in the airways after challenge but there is a conspicuous absence of mucosal production (J:91403)

• mice fail to develop airway hyperresponsiveness (AHR) after first being sensitized and challenged with OVA peptide (J:141937)

• in these mice, inflammation with eosinophil infiltrates occurs in the airways but there is a absence of mucosal producing cells (J:141937)

hematopoietic system

abnormal dendritic cell differentiation ( J:141937 )

• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced although not to the degree found in IL-4 null mice

decreased IgE level ( J:91403 )

• less antigen-specific IgE is made compared to controls during an induced airway hyperresponsiveness model

increased IgG2a level ( J:91403 )

• more antigen-specific IgG2a is made compared to controls during an induced airway hyperresponsiveness model

cellular

abnormal dendritic cell differentiation ( J:141937 )

• numbers of MHCII/CD86-positive dendritic cells found in inflamed lungs are reduced although not to the degree found in IL-4 null mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T-helper 2 cell differentiation ( J:67965 )

• much fewer Th2 cells are developed in vitro when nave CD4 T cells are cultured under Th2-polarizing conditions

• Th2 cells are produced under chronic N. brasiliensis infection

decreased T-helper 2 cell number ( J:67965 )

• much fewer Th2 cells are found in vitro

decreased IgE level ( J:67965 )

• total IgE levels are decreased 5- to 20- fold

increased IgG2b level ( J:67965 )

• there are increased amounts of antigen-specific IgG2b levels when mice are immunized compared to controls

increased IgM level ( J:67965 )

• there are increased amounts of antigen-specific IgM levels when mice are immunized compared to controls

homeostasis/metabolism

decreased circulating interleukin-13 level ( J:67965 )

• IL-13 are absent in these mice

immune system

abnormal T-helper 2 cell differentiation ( J:67965 )

• much fewer Th2 cells are developed in vitro when nave CD4 T cells are cultured under Th2-polarizing conditions

• Th2 cells are produced under chronic N. brasiliensis infection

decreased T-helper 2 cell number ( J:67965 )

• much fewer Th2 cells are found in vitro

decreased IgE level ( J:67965 )

• total IgE levels are decreased 5- to 20- fold

increased IgG2b level ( J:67965 )

• there are increased amounts of antigen-specific IgG2b levels when mice are immunized compared to controls

increased IgM level ( J:67965 )

• there are increased amounts of antigen-specific IgM levels when mice are immunized compared to controls

decreased circulating interleukin-13 level ( J:67965 )

• IL-13 are absent in these mice

increased interferon-gamma secretion ( J:67965 )

• IFN-gamma secretion is 2-fold compared to controls when CD4 T cells are restimulated compared to controls

decreased interleukin-10 secretion ( J:67965 )

• IL-10 secretion is reduced 2-fold compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions

decreased interleukin-4 secretion ( J:67965 )

• IL-4 secretion is dramatically decreased compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions

• schistosome eggs, an antigen that induces Th2 cell responses, induces a 2-fold decreased IL-4 response than controls

decreased interleukin-5 secretion ( J:67965 )

• IL-5 secretion is dramatically decreased compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions

• schistosome eggs, an antigen that induces Th2 cell responses, induces a 2-fold decreased IL-5 response than controls

Allelic Composition	Il13^tm1.1Anjm/Il13^tm1.1Anjm Tg(DO11.10)10Dlo/0
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm1.1Anjm mutation (0 available); any Il13 mutation (30 available)
Tg(DO11.10)10Dlo mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:91403 )

• Th2 T cells from these mice fail to induce airway hyperresponsive when transferred to immunodeficient hosts

decreased interleukin-13 secretion ( J:91403 )

• lymphocytes fail to produce IL-13

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:91403 )

• Th2 T cells from these mice fail to induce airway hyperresponsive when transferred to immunodeficient hosts

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