All Phenotypes Ccr1<tm1Gao> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccr1^tm1Gao/Ccr1^tm1Gao	B6.129S4-Ccr1^tm1Gao	MGI:3614443
hm2	Ccr1^tm1Gao/Ccr1^tm1Gao	involves: 129S4/SvJae	MGI:5317848
hm3	Ccr1^tm1Gao/Ccr1^tm1Gao	involves: 129S4/SvJae * C57BL/6	MGI:3043141
hm4	Ccr1^tm1Gao/Ccr1^tm1Gao	involves: C57BL/6	MGI:3524874
cx5	Apoe^tm1Unc/Apoe^tm1Unc Ccr1^tm1Gao/Ccr1^tm1Gao	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5317889

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal response to cardiac infarction ( J:104744 )

• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:162707 )

• 40% of rMA15 SARS-CoV-infected mice succumb to infection by 7 days post infection

immune system

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to the number of rolling leukocytes

bronchiolitis ( J:162707 )

• rMA15 SARS-CoV-infected mice exhibit more severe denuding bronchiolitis than wild-type mice, with an accumulation of cohesive apoptotic debris within the airway

increased susceptibility to Coronaviridae infection ( J:162707 )

• mice show increased susceptibility to infection with a recombinant mouse-adapted SARS-CoV, rMA15 , developing more severe and prolonged disease compared to wild-type mice, showing more prominent airway epithelial cell apoptosis, severe denuding bronchiolitis and perivenular/periarterial cuffing

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:162707 )

• 40% of rMA15 SARS-CoV-infected mice succumb to infection by 7 days post infection

homeostasis/metabolism

abnormal response to cardiac infarction ( J:104744 )

• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes

cellular

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

hematopoietic system

abnormal cellular extravasation ( J:104744 )

• at 120 min of reperfusion, show a 53.1% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type

abnormal leukocyte adhesion ( J:104744 )

respiratory system

bronchiolitis ( J:162707 )

• rMA15 SARS-CoV-infected mice exhibit more severe denuding bronchiolitis than wild-type mice, with an accumulation of cohesive apoptotic debris within the airway

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:162707

Allelic Composition	Ccr1^tm1Gao/Ccr1^tm1Gao
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr1^tm1Gao mutation (9 available); any Ccr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal Kupffer cell morphology ( J:152548 )

• infiltration of Kupffer cells and NK cells is strongly reduced by bile duct ligation

• fibrosis is reduced after 5 or 21 days

• mediates liver fibrosis primarily through bone marrow derived cells

cardiovascular system

abnormal Kupffer cell morphology ( J:152548 )

• infiltration of Kupffer cells and NK cells is strongly reduced by bile duct ligation

• fibrosis is reduced after 5 or 21 days

• mediates liver fibrosis primarily through bone marrow derived cells

hematopoietic system

abnormal Kupffer cell morphology ( J:152548 )

• infiltration of Kupffer cells and NK cells is strongly reduced by bile duct ligation

• fibrosis is reduced after 5 or 21 days

• mediates liver fibrosis primarily through bone marrow derived cells

immune system

abnormal Kupffer cell morphology ( J:152548 )

• infiltration of Kupffer cells and NK cells is strongly reduced by bile duct ligation

• fibrosis is reduced after 5 or 21 days

• mediates liver fibrosis primarily through bone marrow derived cells

Allelic Composition	Ccr1^tm1Gao/Ccr1^tm1Gao
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr1^tm1Gao mutation (9 available); any Ccr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

impaired hematopoiesis ( J:41324 )

• mutants showed aberrant steady state and induced trafficking of myeloid progenitor cells from marrow to spleen and blood

• mutants displayed aberrant myeloid progenitor cell proliferation

abnormal neutrophil physiology ( J:41324 )

• mature neutrophils from mutant mice failed to mobilize into peripheral blood in vivo in response to MIP-1alpha

immune system

immune system phenotype ( J:41324 )

• no defects in hemostasis or healing of tail wounds, or increased susceptibility to spontaneous infection in a specific pathogen-free environment

• normal histology of bone marrow, lymph node, spleen, and thymus, as well as a complete blood count and differential relative to wild-type

• FACS immunophenotyping of leukocytes from spleen, lymph node, and peripheral blood revealed a normal pattern distribution relative to wild-type

abnormal neutrophil physiology ( J:41324 )

• mature neutrophils from mutant mice failed to mobilize into peripheral blood in vivo in response to MIP-1alpha

granulomatous inflammation ( J:41324 )

• mutants showed impaired lung granuloma formation and type 1-type 2 cytokine balance following i.v. injection of S. mansoni eggs

• mutants developed smaller granulomata relative to wild-type (~40% decreased 14 days after primary egg injection)

• no obvious changes in the cellular composition of these lesions were observed

• the reduction in lesion size was associated with increased IFN-gamma and decreased IL-4 production in mutant versus wild-type lung lymph node cells

increased susceptibility to fungal infection ( J:41324 )

• 70% of mutants challenged with A. fumigatus spores died by day 15; only 20% of wild-type died during the same period

• only 30% of mutants survived beyond 30 days of observation, whereas 60% of control mice remained healthy

• fatally infected mice from both groups exhibited severe ataxia associated with fungal invasion of the CNS 2-3 days prior to death; these symptoms were detected at least 2-3 days earlier in mutants relative to wild-type

• mutants injected with 10⁷ spores exhibited extensive hyphal growth in the kidney, lung, liver, and brain 24 hours after injection; no growth was detected in the brain and lungs of wild-type mice until 72 hours after injection

• none of the infected organs showed hyphal invasion of blood vessels

increased susceptibility to parasitic infection ( J:41324 )

• all mutants succumbed to low-dose T. gondii infection by day 14 post-challenge whereas ~80% of control mice survived the infection in the absence of clinical signs

• all mutants displayed higher tissue parasite loads (10- to 20-fold increase in spleen, liver, lungs, and brain; ~6-fold increase in intestines) relative to control mice

• despite a normal CD4+ T cell immune response against T. gondii, mutants displayed decreased intestinal necrosis, and a reduced PMN index in the intestines at day 2 p.i.

• the influx of PMNs to the peripheral blood and to the liver were also decreased during early infection

Allelic Composition	Ccr1^tm1Gao/Ccr1^tm1Gao
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr1^tm1Gao mutation (9 available); any Ccr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mast cell number ( J:94599 )

• 28% reduction in the number of infiltrating mast cells in the skin 4 hours but not 8 hours after immune complex challenge compared to wild-type

immune system

decreased mast cell number ( J:94599 )

• 28% reduction in the number of infiltrating mast cells in the skin 4 hours but not 8 hours after immune complex challenge compared to wild-type

decreased susceptibility to type III hypersensitivity reaction ( J:94599 )

• 34% reduction in edema, but no difference in hemorrhage, when cutaneous reverse passive Arthus reaction was induced compared to wild-type

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ccr1^tm1Gao/Ccr1^tm1Gao
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Ccr1^tm1Gao mutation (9 available); any Ccr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atherosclerotic lesions ( J:128063 )

• increased plaque size on a high fat diet

immune system

increased interferon-gamma secretion ( J:128063 )

• increased number of secreting cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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