homeostasis/metabolism
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• female carriers are viable, fertile and overtly normal on the basis of size, activity, and liver histology with no significant changes in clotting times after tail snipping
• however, female carriers exhibit a mean plasma F. IX titer of 35 U/dL relative to 92 and 69 U/dL obtained in wild-type littermates (male and female) and wild-type females, respectively
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